【摘 要】 目的 探讨抑癌基因PTEN和FHIT与非小细胞肺癌发生、发展的关系。 方法 应用免疫组化Elivision法检测78例非小细胞肺癌组织和40例非肿瘤肺组织中PTEN和FHIT在基因蛋白的表达。 结果 非肿瘤肺组织FHIT和PTEN蛋白阳性表达率明显高于肺癌组织(P<0.05);肺癌组织中FHIT和PTEN蛋白阳性表达率与肿瘤分化程度和临床分期有明显相关性(P<0.05);而FHIT和PTEN蛋白的阳性表达率在不同类型肺癌组织以及患者年龄、肿瘤大小、有无淋巴结转移等情况的比较中差异无显著性(P>0.05)。 结论 PTEN和FHIT基因蛋白表达缺失在不同类型和不同分化程度的非小细胞肺癌发生、发展中可能存在着普通意义，可作为判断肺癌生物学行为和患者预后的参考指标。

    【关键词】 非小细胞肺癌;PTEN蛋白;FHIT蛋白;表达;免疫组织化学

    Expression of PTEN and FHIT protein in non┐small cell lung carcinoma and their clinicopathologic relationship

    ZHANG Qiong，ZHU Yu-zhao，MA Li，et al.

    (Department of Pathology，Bengbu Medical College，Anhui Bengbu233003，China)

    【Abstract】 Objective To investigate the relationship between the expression of FHIT and PTEN proteins and the significance of FHIT and PTEN gene in non-small cell lung carcinoma(NSCLC).Methods The expression of FHIT and PTEN proteins in78cases of lung carcinoma and non-neoplasia tissues was tested by immunohistochemical Elivision method.Results The rate of expression of FHIT and PTEN proteins in tumor tissues was significantly lower than that in non-tumor tissues(P<0.05).It was shown that FHIT and PTEN proteins'expression had no relationship with clinicopathologic factors including age ......