WANG Shuª²Min1, MA Yingª²Yan2, CHENG Qingª²Shu3

    1Department of Thoracic Surgery, 2Department of Cardiology, General Hospital of Shenyang Military Area Command, Shenyang 110015, China, 3Department of Thoracic Surgery, Tangdu Hospital, Fourth Military Medical University, Xi¬ðan 710038, China

    ¡¾Abstract¡¿ AIM: To discuss the expressions of the apoptosisª²related oncogenes Fas, Bclª²2, Bax and p53 in lung cancer tissues and their significance, in order to provide the theoretical basis for the molecular biological study. METHODS£º The expressions of p53, Bclª²2, Bax and Fas proteins in 57 cases of lung cancer were detected by the immunohistochemical technique and TUNEL. RESULTS£º The expression rates of Bclª²2, p53, Bax, Fas proteins in lung cancer tissues were 33%, 69%,70% and 28%, respectively,and the expression rate of each apoptosisª²related oncogene was different in lung cancer tissues of the different pathologic types. There was no definite relationship between the lymph node metastasis and the apoptosisª²related oncogenes(P<0.05). With the rising of the pathologic staging of the tumor , the expressions of p53 and Fas proteins increased, while the expression of Bclª²2 decreased. There seemed to be no definite relationship between the expression of Bax protein and the pathological staging(P<0.05).CONCLUSION£º There are the apoptosisª²related oncogene expressions in lung cancer tissues, and their expression degree is related with their pathological types. The overª²expressions of p53 and Fas proteins may be associated with the bad prognosis of lung cancer. ......