胰腺导管腺癌组织中WT1, IGF-IR表达与细胞凋亡的关系
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龚 勇, 赵 秋, 杨 芳, 王 渝, 马松林
Wilms肿瘤基因;胰岛素样生长因子I受体;胰腺导管腺癌;免疫组织化学;细胞凋亡,胰腺导管腺癌组织中WT1,IGF-IR表达与细胞凋亡的关系,龚勇,赵秋,杨芳,王渝,马松林,通讯作者:,电话:
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龚勇, 赵秋, 杨芳, 王渝, 马松林, 华中科技大学同济医学院附属同济医院消化内科 湖北省武汉市 430030
通讯作者: 赵秋, 430030, 湖北省武汉市汉口解放大道1095号, 华中科技大学同济医学院附属同济医院消化内科.
tongji461@sina.com
电话: 027-83663611
收稿日期: 2006-07-31 接受日期: 2006-08-15
Relationship between expression of Wilms' tumor gene, insulin-like growth factor Ⅰ receptor and cell apoptosis in human pancreatic duct adenocarcinoma
Yong Gong, Qiu Zhao, Fang Yang, Yu Wang, Song-Lin Ma
Yong Gong, Qiu Zhao, Fang Yang, Yu Wang, Song-Lin Ma, Department of Gastroenterology, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei Province, China
Correspondence to: Qiu Zhao, Department of Gastroenterology, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei Province, China. tongji461@sina.com
Received: 2006-07-31Accepted: 2006-08-15
Abstract
AIM:To investigate the roles of Wilms' tumor gene (WT1), insulin-like growth factorⅠreceptor expression (IGF-IR) and cell apoptosis as well as their correlations in human pancreatic duct adenocarcinoma.
METHODS: Immunohistochemical analysis was used to detect the expression of WT1 and IGF-IR in human pancreatic duct adenocarcinoma (n = 49) and normal pancreatic tissues (n = 15). The cell apoptosis of pancreatic duct adenocarcinoma was estimated by terminal deoxynucleotidyl transferase mediated dUTP nick end labeling (TUNEL) method and apoptosis index (AI) was calculated.
RESULTS: In normal pancreatic tissues, the positive rates of WT1, IGF-IR were 26.67% (4/15), 40.00% (6/15), respectively, and in pancreatic duct adenocarcinoma their positive rates were 71.43% (35/49), 77.55% (38/49), respectively. There were significant differences between cancer and normal tissues (P < 0.05). A positive relationship existed between the expression of WT1 and IGR-IR in pancreatic duct adenocarcinoma (r = 0 ......
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