当前位置: 首页 > 期刊 > 《世界华人消化杂志》 > 2006年第28期
编号:11319672
结直肠癌中PTEN的缺失表达及临床意义
http://www.100md.com 李 季, 田素礼, 李 巍, 李福蕴
结直肠癌;癌旁组织;PTEN基因;转移李季,田素礼,李巍,李福蕴.结直肠癌中PTEN的缺失表达及临床意义. 世界华人消化杂志2006;14(28)2771-2775,结直肠癌中PTEN的缺
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     李季, 田素礼, 李巍, 哈尔滨医科大学附属二院普外二科 黑龙江省哈尔滨市 150086

    李福蕴,
安达市中医院 黑龙江省安达市 151400

    通讯作者:
田素礼, 150086, 黑龙江省哈尔滨市保健路157号, 哈尔滨医科大学附属第二医院普外二科. liji_hangyuan@sohu.com

    电话:
0451-86605044

    收稿日期:
2006-05-20 接受日期: 2006-06-05

    Down-regulated expression of PTEN in colorectal cancer and its clinical significance

    Ji Li, Su-Li Tian, Wei Li, Fu-Yun Li

    Ji Li, Su-Li Tian, Wei Li, the Second Department of General Surgery, the Second Affiliated Hospital of Harbin Medical University, Harbin 150086, Heilongjiang Province, China

    Fu-Yun Li,
Anda Hospital of Chinese Medicine, Anda 151400, Heilongjiang Province, China

    Correspondence to:
Su-Li Tian, the Second Department of General Surgery, the Second Affiliated Hospital of Harbin Medical University, 157 Baojian Road, Harbin 150086, Heilongjiang Province, China. liji_hangyuan@sohu.com

    Received:
2006-05-20Accepted: 2006-06-05

    AbstractAIM:To study the expression of PTEN in colorectal carcinoma and its correlation with the clinicopathological features.

    METHODS:Immunohistochemical SP technique was used to determine the expression of PTEN protein in 65 cases of colorectal carcinoma and their corresponding adjacent tissues, 13 cases of adenoma tissues, and 20 cases of normal colorectal tissues.

    RESULTS:The expression of PTEN protein was mainly located in the nucleus and cytoplasm. The expression of PTEN protein was significantly lower in human colorectal cancer tissues than that in the corresponding adjacent tissues ones (56.92% vs 86.15%, P < 0.01), and it was also markedly lower in the lowly- and non-differentiated adenoma than that in the highly-and moderately-differentiated one (37.50% vs 75.76%, P < 0.01). The expression of PTEN protein in Dukes A and B stages were significantly higher than that in in Dukes C and D stages (73.33% vs 42.86%, P < 0.05). In addition, PTEN expression was correlated with lymph node metastasis (c2= 7 ......

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