survivin反义寡核苷酸对胰腺癌荷瘤裸鼠的治疗作用
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刘江伟, 张永久, 皇甫清风, 李开宗, 张 东,
胰腺癌;survivin;反义寡核苷酸;裸鼠,刘江伟,张永久,张东,雷涛,皇甫清风,李开宗,刘江伟,通讯作者:,Therapeu
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刘江伟, 张永久, 张东, 雷涛, 兰州军区乌鲁木齐总医院普外科 新疆维吾尔自治区乌鲁木齐市 830000
皇甫清风, 兰州军区乌鲁木齐总医院干部病房 新疆维吾尔自治区乌鲁木齐市 830000
李开宗, 第四军医大学西京医院肝胆外科 陕西省西安市 710032
刘江伟, 博士, 副主任医师, 主要从事普外科基础与临床研究.
通讯作者: 刘江伟, 830000, 新疆维吾尔自治区乌鲁木齐市友好北路41号, 兰州军区乌鲁木齐总医院普外科. ljw273@sohu.com
电话: 0991-4992101-305
收稿日期: 2006-07-09 接受日期: 2006-08-10
Therapeutic effects of survivin antisense oligonucleotide on nude mice bearing human pancreatic carcinoma xenograft
Jiang-Wei Liu, Yong-Jiu Zhang, Qing-Feng Huangfu, Kai-Zong Li, Dong Zhang, Tao Lei
Jiang-Wei Liu, Yong-Jiu Zhang, Dong Zhang, Tao Lei,Department of General Surgery, Urumqi General Hospital of Lanzhou Military Command, Chinese PLA, Urumqi 830000, Xinjiang Uygur Autonomous Region, China
Qing-Feng Huangfu,Department of Carder Ward, Urumqi General Hospital of Lanzhou Military Command, Chinese PLA, Urumqi 830000, Xinjiang Uygur Autonomous Region, China
Kai-Zong Li,Department of Hepatobiliary Surgery, Xijing Hospital, the Fourth Military Medical University of Chinese PLA, Xi’an 710032, Shaanxi Province, China
Correspondence to:Jiang-Wei Liu, Department of General Surgery, Urumqi General Hospital of Lanzhou Military Region, Chinese PLA, 41 Youhao North Road, Urumqi 830000, Xinjiang Uygur Autonomous Region,China. ljw273@sohu.com
Received:2006-07-09 Accepted: 2006-08-10
Abstract
AIM: To investigate the therapeutic effects of survivin antisense oligonucleotide (ASODN) on nude mice bearing human pancreatic carcinoma xenograft.
METHODS: The nude mouse model of pancreatic cancer was established using human pancreatic cancer cell line BxPC-3. The mice bearing tumor were intratumorally injected with survivin ASODN (40 g/200 L per mouse). The tumor size and volume were measured before and after injection. The pathological changes of tumor tissues were observed. The expression level of survivin mRNA was measured by reverse transcription-polymerase chain reaction (RT- PCR), and the activity of caspase-3 was evaluated using a caspase-3 assay kit ......
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