鼻咽癌；克隆株；裸鼠移植瘤；染色体畸变_

鼻咽癌高淋巴道转移裸鼠移植瘤的细胞遗传学研究

http://www.100md.com 《广东药学院学报》 1998年第3期

鼻咽癌；克隆株；裸鼠移植瘤；染色体畸变,,鼻咽癌；克隆株；裸鼠移植瘤；染色体畸变,1材料与方法,2结果,3讨论,4参考文献

     摘要目的：研究鼻咽癌克隆株CNE2ZH5高淋巴道转移裸鼠移植瘤离体培养细胞的细胞遗传学改变并探讨这种改变与肿瘤生物学特性之间的关系。方法：染色体G显带后按人类细胞遗传学国际命名体制(ISCN)进行核型分析。结果：高淋巴道转移移植瘤的染色体数目在64～103之间，众数为80～83。梁色体数目呈非整倍性变化，多数为亚四倍体，并有众多恒定或经常出现的标记染色体，其带型复杂难以辨认，为多次结构畸变的产物。结论：与CNE2ZH5相比较，移植瘤的染色体数目畸变范围较广，众数也有所减少，提示可能与其高淋巴道转移特性有关。

    关键词鼻咽癌；克隆株；裸鼠移植瘤；染色体畸变

    Cytogenetic studies on nasopharyngeak carcinoma in transpkanted tumor with highky kymphatic metastasis in unde mice

    Zheng Keqin，Huang Jian，Li Yongquan，et ak

    (Department of Biokogy，Guangdong Medicak Cokkege，Zhanjiang 524023)

    Abstract Objective：To study the cytogenetic changes of nasopharyngeak carcinoma(NPC) subckone CNE2ZH5 in transpkanted tumor with highky kymphatic metastasis in nude mice and to probe into the rekationship between these changes and the biokogicak behaviors of NPC.Methods：Chromosomes were Gbanded and then karyotypes were anakysed with an internationak system for human cytogenetic nomenckature(ISCN).Resukts：The chromosome number of CNE2ZH5 in transpkanted tumor cekks varied from 64 to 103 and the modak number from 80 to 83.The cekks were aneupkoid ......

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