ZHOU Bin1, YU Bo1, YAO Nan2, SONG Shaoª²Li2

    1Cadre¡¯s Health Care Center of Gansu Province, Lanzhou 730020, China, 2First Hospital of Lanzhou University, Lanzhou 730000, China

    ¡¾Abstract¡¿ AIM£ºTo explore the protective mechanism of Panax notoginoside (PNS) against hepatic injury after obstructive jaundice (OJ) in rabbits. METHODS£ºFortyª²eight healthy Japanese white rabbits were randomized into 2 groups, 24 in each group: group A treated with common bile duct ligation (BDL), group B of BDL + PNS. All animals were kept under the same condition. Immunohistochemistry was used to determine the expressions of Bax and Bclª²2 in hepatic tissues. RESULTS£º In group A, expressions of bclª²2 and bax in the hepatic tissue were observed after OJ. Expression of bax reached the peak at the 9th day after OJ, then tended to decline. Similarly, the highest expression of bclª²2 was observed at the 21th day after OJ. The apoptosis index (AI) increased with the increase of bax expression but decreased with bclª²2 strong expression. After treatment with PNS in group B, a lower expression of bax and a higher expression of bclª²2 were found, and the AI value was also lower, compared with group A. CONCLUSION£º The pathology of OJ may be related to the initiation of apoptosis. PNS may play a protective role against hepatic injury after OJ, which may be realized through upª²regulating the expression of bclª²2 and downª²regulating the expression of bax in the hepatic tissues. ......