紫杉醇；子宫内膜肿瘤；_子宫内膜癌细胞珠；_增殖；

紫杉醇诱导人子宫内膜癌细胞增殖凋亡的实验研究

http://www.100md.com 《第四军医大学学报》 2006年第17期

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     Experimental study on human endometrial adenocarcinoma cell apoptosis induced by taxol

    GAN Quan, XIN XiaoYan, LIU Yu, WANG DeTang, GUO HuiLing

    1Department of Obstetrics and Gynaecology, Xijing Hospital, Fourth Military Medical University, Xian 710033, China

    2Department of Obstetrics and Gynaecology, Yunnan Provincial Corps Hospital, Chinese People’s Armed Police Forces, Kunming 650111, China

    【Abstract】 AIM： To investigate the inhibition of proliferation and induction of apoptosis in vitro cultured human endometrial adenocarcinoma cell (HEC1B) by taxol. METHODS： Human endometrial adenocarcinoma HEC1B cells were cultured in vitro and treated with 2， 4， 8， 16， 20 nmol/L taxol for 48 h. Cell apoptosis was observed by nuclear staining and fluorescence microscopy and intracellular calcium fluorescence pixel values of live cells were detected by laser scanning confocal microscope. RESULTS: Through the blockage of caspase pathway with caspase3 inhibitor， taxol induced apoptosis was suppressed in endometrial carcinoma cells. CONCLUSION: Taxol inhibits the proliferation and induces the apoptosis of human endometrial adenocarcinoma HEC1B cells. ......

百拇医药网 http://www.100md.com/html/DirDu/2006/11/14/29/39/45.htm

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