东北地区汉族人群DNA修复基因XPD单核苷酸多态性与胃癌的相关性
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娄 毅, 宋清斌, 何向民
胃癌;XPD基因;单核苷酸多态娄毅,宋清斌,何向民.东北地区汉族人群DNA修复基因XPD单核苷酸多态性与胃癌的相关性. 世界华人消化杂志2006;14(32)3143-3146
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娄毅, 中国医科大学基础医学院医学遗传学教研室 辽宁省沈阳市 110001
宋清斌, 中国医科大学附属第一医院普通外科 辽宁省沈阳市 110001
何向民, 中国医科大学附属第一医院消化内科 辽宁省沈阳市 110001
通讯作者: 娄毅, 110001, 辽宁省沈阳市和平区北二马路92号, 医学遗传学教研室. louyi_1963_1019@163.com
电话: 024-23256666-5324
收稿日期: 2006-09-01 接受日期: 2006-09-25
Association of single nucleotide polymorphism in DNA repair gene XPD with gastric cancer in Han population from northeast region of China
Yi Lou, Qing-Bin Song, Xiang-Min He
Yi Lou, Department of Medical Genetics, China Medical University, Shenyang 110001, Liaoning Province, China
Qing-Bin Song, Department of General Surgery, the First Affiliated Hospital of China Medical University, Shenyang 110001, Liaoning Province, China
Xiang-Min He, Department of Gastroenterology, the First Affiliated Hospital of China Medical University, Shenyang 110001, Liaoning Province, China
Correspondence to: Yi Lou, Department of Medical Genetics, China Medical University, Shenyang 110001, Liaoning Province, China. louyi_1963_1019@163.com
Received: 2006-09-01 Accepted: 2006-09-25
Abstract
AIM: To assess the relationship between XPD single nucleotide polymorphism (SNP) and susceptibility to gastric cancer in Han Chinese from northeast region via a hospital-based, case-control study.
METHODS: Polymerase chain reaction-restriction fragment length polymorphism analysis was used to determine the Asp312Asn and Lys751Gln polymorphisms of XPD gene in 238 patients with gastric cancer and 200 healthy controls ......
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