肝硬化患者肝组织中PCNA和Ki-67的表达
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权春姬, 金仁顺, 朴东明
肝硬化;慢性肝炎;增殖细胞核抗原;Ki-67抗原权春姬,金仁顺,朴东明.肝硬化患者肝组织中PCNA和Ki-67的表达. 世界华人消化杂志2006;14(32)3151-3154,肝硬化患者
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权春姬, 金仁顺, 朴东明, 延边大学附属医院病理科 吉林省延吉市 133000
通讯作者: 朴东明, 133000, 吉林省延吉市局子街1327号, 延边大学附属医院病理科. pdm1117@hotmail.com
电话: 0433-2660121 传真: 0433-2513610
收稿日期: 2006-08-30 接受日期: 2006-09-20
Expression of proliferating cell nuclear antigen and Ki-67 antigen in liver tissues of cirrhotic patients
Chun-Ji Quan, Ren-Shun Jin, Dong-Ming Piao
Chun-Ji Quan, Ren-Shun Jin, Dong-Ming Piao, Department of Pathology, the Affiliated Hospital of Yanbian University, Yanji 133000, Jilin Province, China
Correspondence to:Dong-Ming Piao, Department of Pathology, the Affiliated Hospital of Yanbian University, 1327 Juzi Street, Yanji 133000, Jilin Province, China. pdm1117@hotmail.com
Received:2006-08-30 Accepted:2006-09-20
Abstract
AIM: To investigate the expression and significances of proliferating cell nuclear antigen (PCNA) and Ki-67 antigen in liver tissues of cirrhotic patients.
METHODS: SP immunohistochemical technique was performed to detect the expression of PCNA and Ki-67 in 58 liver specimens from patients with cirrhosis from hepatitis B (n = 24) and hepatitis C (n = 22), and chronic hepatitis (n = 12), and the labeling index (LI) of the positive cells was also determined. Sirius red staining was used to determine the area density of collagen in liver tissues.
RESULTS: The expression of PCNA and Ki-67 LI was significantly higher in chronic hepatitis than that in cirrhosis (34.67% ± 8.6% vs 10.38% ± 3.76%, P < 0.001; 2.81% ± 0.51% vs 1.69% ± 1.03%,P < 0.001), and moreover, they were markedly higher in hepatitis C-induced cirrhosis than those in hepatitis B-induced one (13.12% ± 1.42% vs 6.32% ± 2.18%, P < 0.001; 2.48% ± 0.54% vs 0.95% ± 0.77%, P < 0.001). The area density of collagenous fiber was significantly increased in cirrhosis than that in chronic hepatitis (12.0 ± 3.1 vs 1.40 ± 1.0, P < 0.001), but there was no difference between the two types of cirrhosis (P > 0 ......
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