血管紧张素Ⅱ拮抗剂在大鼠应激性溃疡中的作用
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窦勇鹰, 谢立群, 李俊美, 华建平, 海 鸥
血管紧张素;胃黏膜;血管;血栓素B2;6-酮前列腺素F1α;应激性溃疡,窦勇鹰,谢立群,海鸥,李俊美,华建平,通讯作者:,Roleofangiote
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窦勇鹰, 谢立群, 海鸥, 中国人民武装警察部队医学院附属医院消化内科 天津市 300162
李俊美, 华建平, 天津市第一中心医院消化内科 天津市 300192
通讯作者: 谢立群, 300162, 天津市河东区, 中国人民武装警察部队医学院附属医院消化内科. xieliqun66@hotmail.com
电话: 022-60578765
收稿日期: 2006-07-13 接受日期: 2006-08-10
Role of angiotensin Ⅱ antagonist in the formation of stress ulcer in rats
Yong-Ying Dou, Li-Qun Xie, Jun-Mei Li, Jian-Ping Hua, Ou Hai
Yong-Ying Dou, Li-Qun Xie, Ou Hai,Department of Gastroenterology, the Affiliated Hospital of Medical College of Chinese People's Armed Police Forces, Tianjin 300162, China
Jun-Mei Li, Jian-Ping Hua,Department of Gastroenterology, the First Central Hospital of Tianjin Municipality, Tianjin 300192, China
Correspondence to:Li-Qun Xie, Department of Gastroenterology, the Affiliated Hospital of Medical College of Chinese People's Armed Police Forces, He Dong district, Tianjin 300162, China. xieliqun66@hotmail.com
Received:2006-07-13 Accepted:2006-08-10
Abstract
AIM: To investigate the role of angiotensins Ⅱ antagonist in the occurrence and development of stress ulcer in rats.
METHODS: The ulcer index (UI) was observed after water immersion-restaint stress (WRS), and the levels of thromboxane B2 (TXB2) and 6-ketoprostaglandin F1 alpha (6-K) were measured by radioimmunoassay. The gastric mucosal pH value was detected and histopathological changes were observed.
RESULTS: In comparison with those in the negative controls, the gastric mucosal pH value and 6-K level were significantly increased in the antagonist group (4.82 ± 0.31 vs 4.53 ± 0.11, P = 0.026; 974.95 ± 109.11 ng/L vs 654.50 ± 221.31 ng/L, P < 0.01), but the TXB2 level and UI were significant decreased (48.53 ± 8.26 ng/L vs 98.18 ± 39.24 ng/L, P < 0.01; 36.13 ± 6.49 vs 69.00 ± 33.27, P < 0.01). Meanwhile, thrombosis was also decreased in the antagonist group. The level of 6-K was significantly different between the antagonist and positive control group (974 ......
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