缺氧对大鼠肝细胞转化生长因子β1表达的影响
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李 侠, 詹 皓, 齐 颖, 王 琼, 赵安东,
缺氧;转化生长因子β1;肝细胞;大鼠;免疫组化,缺氧对大鼠肝细胞转化生长因子β1表达的影响,李侠,詹皓,齐颖,王琼,赵安东,王喆,笪冀平,施新猷,李侠,通讯作者:,Effectsofa
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李侠, 詹皓, 齐颖, 王琼, 赵安东, 中国人民解放军空军航空医学研究所 北京市 100036
王喆, 笪冀平, 中国人民解放军空军总医院病理科 北京市 100036
施新猷, 第四军医大学动物实验室 陕西省西安市 710032
李侠, 1998年第四军医大学硕士, 主任医师, 主要从事临床医学及病理生理的分子生物学研究.
通讯作者: 李侠, 100036, 北京市海淀区阜成路28号一室, 中国人民解放军空军航空医学研究所. jbslawyer158@sina.com
电话: 010-81817155 传真: 010-66927100
收稿日期: 2006-08-21 接受日期: 2006-09-12
Effects of anoxia on expression of transforming growth factor-β1 in rat liver
Xia Li, Hao Zhan, Ying Qi, Qiong Wang, An-Dong Zhao, Zhe Wang, Ji-Ping Da, Xin-You Shi
Xia Li, Hao Zhan, Ying Qi, Qiong Wang, An-Dong Zhao,Institute of Aviation Medicine, Chinese PLA Air Force, Beijing 100036, China
Zhe Wang, Ji-Ping Da,Department of Pathology, General Hospital of Chinese PLA Air Force, Beijing 100036, China
Xin-You Shi,Department of Animal Laboratory, the Fourth Military Medical University, Xi’an 710032, Shaanxi Province, China
Correspondence to:Dr. Xia Li, Institute of Aviation Medicine, Chinese PLA Air Force, 28 Fucheng Road, Haidian District, Beijing 100036, China. jbslawyer158@sina.com
Received:2006-08-21 Accepted:2006-09-12
Abstract
AIM: To investigate the effect of anoxia on the expression of transforming growth factor-β1 (TGF-β1) in the rat liver.
METHODS: A total of 20 Sprague Dawley rats were used in this study. Trachea obstructive method was employed to establish the animal model of mild, moderate, and severe anoxia. Liver samples were collected 15 and 60 min after obstruction for the examination of TGF-β1 expression using immunohistochemical technique.
RESULTS: TGF-β1 was not or lowly expressed in normal rats (3.6 ± 1.9 and 3.6 ± 1.9, respectively at 15 and 60 min). The level of hepatic TGF-β1 expression was increased with prolonging of anoxia time and enhancement of anoxia degree ......
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