[摘要] [目的] 研究大豆磷脂对小鼠酒精性肝损伤的保护作用. [方法] 建立小鼠酒精性肝损伤模型，设空白对照组、肝损伤模型组和大豆磷脂小、中、大剂量(0.12，0.24，0.48g/kg)组，给予相应处理7d后测定血清中ALT，AST含量和肝匀浆液中MDA，GSH含量. [结果] 大豆磷脂大剂量组小鼠血清中ALT含量及中、大剂量大豆磷脂组小鼠血清中AST含量均较肝损伤模型组低，大豆磷脂各剂量组小鼠肝组织内MDA含量显著低于肝损伤模型组，大豆磷脂大剂量组小鼠肝组织内GSH含量明显高于肝损伤模型组. [结论] 大豆磷脂对酒精性肝损伤具有保护作用.

    [关键词] 肝疾病，酒精性;植物，药用;小鼠

    Protective effects of soybean phosphorlipid on ethanol-induced hepatotoxicity in mice

    KANG Dong-zhou 1 ，ZHAO Lian-fang 2 ，QUAN Xian-hua 3

    (1.Yanbian University College of Pharmacy;2.Yanbian University College of Nursing;3.Yanbian Traditional Hospital:Yanji133000，Jilin，China)

    ABSTRACT:OBJECTIVE To study the protective effects of soybean phosphorlipid on ethanol-induced hepatotoxicity in mice.METHODS The liver injury models were induced by ethanol in mice ......