[摘要] [目的] 研究沙棘汁对醋酸铅所致小鼠脑脂质过氧化及胆碱酯酶和单胺类神经递质含量改变的影响. [方法] 制作铅中毒小鼠模型，灌胃给予不同剂量的沙棘汁，利用硫代巴比妥酸比色法、碱性羟胺法及荧光法分别测定小鼠脑组织内过氧化脂质、胆碱酯酶及单胺类神经递质含量. [结果] 铅组小鼠脑组织内MDA含量明显升高，200，400g/L沙棘汁降低铅致MDA含量升高，且呈剂量-效应关系;铅组小鼠脑组织内胆碱酯酶活性明显升高，单胺类神经递质中除DA外NE，5-HT，5-HIAA含量均明显下降，400g/L沙棘汁抑制铅致脑组织内多种神经递质含量的变化. [结论] 沙棘汁可拮抗铅所致小鼠脑组织内脂质过氧化及胆碱酯酶和单胺类神经递质含量的改变.

    [关键词] 脂质过氧化作用;生物源单胺类;胆碱酯酶类;植物，药用;小鼠

    Effects of the Hippophae Rhamnoides L juice on lead-induced change of lipid peroxidation，acetylcholinesterase and catecholamine neurotrans-mitters in mice brain

    XU Yan-ji，HAN Chun-ji，LI Lian-ji

    (Department of Hygiene，Yanbian University College of Basic Medicine，Yanji133000，Jilin，China)

    ABSTRACT:OBJECTIVE To study the effects of the Hippophae Rhamnoides L juice on lead-induced change of lipid peroxidation，acetylcholinesterase(AchE)and catecholamine neurotransmitters in mice brain.METHODS Mice were administrated peritoneal injection with lead acetate ......