MTA1基因表达与人胃癌的浸润和转移
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刘 海, 胡俊波, 王志强, 卫子然
转移相关基因1;基因表达;胃癌;肿瘤转移刘海,胡俊波,王志强,卫子然.MTA1基因表达与人胃癌的浸润和转移. 世界华人消化杂志2006;14(34)3317-3320,MTA1基因表达与人
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刘海,中建二局二公司职工医院 华中科技大学同济医学院附属同济医院胃肠外科中心在职硕士研究生 湖北省武汉市 430030
胡俊波, 王志强, 卫子然,华中科技大学同济医学院附属同济医院胃肠外科中心 湖北省武汉市 430030
通讯作者:胡俊波, 430030, 湖北省武汉市解放大道1095号, 华中科技大学同济医学院附属同济医院胃肠外科中心. wangzq0808@sina.com
电话:027-83663816 传真:027-83663400
收稿日期: 2006-09-12 接受日期:2006-09-28
Expression of metastasis-associated gene 1 and its correlation with invasion and metastasis of human gastric carcinoma
Hai Liu, Jun-Bo Hu, Zhi-Qiang Wang, Zi-Ran Wei
Hai Liu, Jun-Bo Hu, Zhi-Qiang Wang, Zi-Ran Wei, Center of Gastrointestinal Surgery, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei Province, China.
Correspondence to: Dr. Jun-Bo Hu, Center of Gastrointestinal Surgery, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei Province, China. wangzq0808@sina.com
Received: 2006-09-12 Accepted: 2006-09-28
Abstract
AIM: To investigate the expression of metastasis-associated gene 1 (MTA1) in human gastric carcinoma and its correlation with tumor metastasis.
METHODS:Real time polymerase chain reaction (PCR) and Western blot were employed to detect the expression of MTA1 in gastric carcinoma and its adjacent gastric mucosa obtained from the surgical specimens of 42 patients, and the correlation between the expression of MTA1 and the differentiation and metastasis of gastric carcinoma were investigated.
RESULTS:The expression of MTA1 mRNA in gastric carcinoma was significantly higher than that in the adjacent gastric mucosa (0 ......
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