系统检测慢性乙型肝炎患者外周血淋巴细胞免疫表型的临床意义
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吴引伟, 文 剑, 赵 伟, 张 亮, 宋玉华,
淋巴细胞;免疫表型;流式细胞术;乙肝病毒;慢性乙型肝炎吴引伟,文剑,赵伟,张亮,宋玉华,谈国蕾,赵磊.系统检测慢性乙型肝炎患者外周血淋巴细胞免疫表型的临床意义.世界华人消化杂志2006;14(34)3
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吴引伟, 文剑, 赵伟, 张亮, 宋玉华, 谈国蕾, 赵磊, 东南大学医学院附属南京市第二医院细胞室 江苏省南京市 2100032003年度南京市医学科技发展项目, No. YKK0328;
2003年度江苏省社会发展指导性项目, No. BS2003601
通讯作者:吴引伟, 江苏省南京市鼓楼区钟阜路1号, 南京市第二医院细胞室. njchongchong@163.com
电话:025-83432214-2155 传真:025-83471484
收稿日期:2006-08-28 接受日期:2006-09-20
Clinical values of systemic analysis of peripheral blood mononuclear cell subsets in patients with chronic hepatitis B
Yin-Wei Wu, Jian Wen, Wei Zhao, Liang Zhang, Yu-Hua Song, Guo-Lei Tan, Lei Zhao
Yin-Wei Wu, Jian Wen, Wei Zhao, Liang Zhang, Yu-Hua Song, Guo-Lei Tan, Lei Zhao, Cell Laboratory, the Second Hospital of Nanjing Affiliated to Medical College of Southeast University, Nanjing 210003, Jiangsu Province, China
Supported by the Medical Science and Technology Foundation of Nanjing City, Jiangsu Province, No.YKK0328, and the Societal Directive Research Programs of Science and Technology Commission of Jiangsu Province, No.BS2003601
Correspondence to: Yin-Wei Wu, Cell Laboratory, the Second Hospital of Nanjing Affiliated to Medical College of Southeast University, 1 Zhongfu Road, Gulou District, Nanjing 210003, Jiangsu Province,China. njchongchong@163.com
Received: 2006-08-28 Accepted: 2006-09-20
Abstract
AIM: To study the clinical values of systemic detection for peripheral blood mononuclear cell (PBMC) subsets in patients with chronic hepatitis B (CHB).
METHODS:Flow cytometry (FCM) was used to detect the expression of CD3, CD4, CD5, CD25, CD28 and CD38 in peripheral blood lymphocytes from 28 CHB patients and 22 healthy controls, and their correlations between the quantification of hepatitis B virus (HBV) DNA.
RESULTS:The levels of CD4+CD25+, CD8+HLADR+CD38+, CD3-CD19+, CD5-CD19+ and CD19+CD38+ lymphocytes in CHB patients with chronic hepatitis B were significantly higher than those in the controls (t = 2 ......
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