Expressions and significance of PCNA and MMP9 in cervix cancer tissue

    SUN Hong, WANG Hao, QIN Tianª²Jie, RUAN Zhiª²Ping, MA Jinª²Lu

    Department of Oncology, First Affiliated Hospital, Xi¬ðan Jiaotong University, Xi¬ðan 710061, China

    ¡¾Abstract¡¿ AIM: To investigate the expressions of PCNA and MMP9 in cervix cancer tissue and their significance. METHODS: The immunohistochemical SP staining method was used to evaluate the PCNA and MMP9 expressions in 46 cases of cervix cancer tissues and 10 cases of normal cervix tissues. RESULTS: The expression of PCNA in cervix cancer tissues was much higher than that in normal cervix tissues (P=0.000)£»The positive rate of MMP9 protein 82.61% in 46 cases of cervix cancer was significantly higher than that in 10 cases of normal cervix (30%, P<0.05). There was a positive correlation between PCNA and MMP9 expressions (rs=0.433, P=0.003). The expressions of PCNA and MMP9 were correlated with the clinical stage (P<0.05), but not with age, pathological stage or growth pattern (P>0.05). CONCLUSION: The overª²expression of MMP9 has a close relationship with the cell proliferation index in cervix cancer, suggesting that MMP9 may play an important role in the development of cervix cancer. ......