非酒精性脂肪肝大鼠肝脏硬脂酰CoA去饱和酶-1表达与ATP浓度之间的关系
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陆元善, 范建高, 方继伟, 丁晓东, 杨兆瑞
非酒精性脂肪肝;硬脂酰CoA去饱和酶-1;三磷酸腺苷;实时荧光RT-PCR陆元善,范建高,方继伟,丁晓东,杨兆瑞.非酒精性脂肪肝大鼠肝脏硬脂酰CoA去饱和酶-1表达与ATP浓度之间的关系. 世界华人消化杂志2006;14(36)3450-3456,非酒精性脂肪肝大鼠肝脏硬脂酰CoA去饱和
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陆元善, 上海交通大学附属第一人民医院检验科 上海市 200080
范建高, 方继伟, 丁晓东, 上海交通大学附属第一人民医院消化科 上海市 200080
杨兆瑞, 上海交通大学附属第一人民医院病理科 上海市 200080
陆元善, 1998年上海医科大学硕士, 主任技师, 主要从事血脂及其相关疾病研究.
通讯作者: 陆元善, 200080, 上海市虹口区武进路85号, 交通大学附属第一人民医院检验科. luyuanshan@126.com
电话: 021-63240090-4306
收稿日期: 2006-08-26 接受日期: 2006-09-20
Relationship between hepatic stearoyl-CoA desaturase-1 expression and adenosine triphosphate content in rats with nonalcoholic fatty liver caused by fat-rich diet
Yuan-Shan Lu, Jian-Gao Fan, Ji-Wei Fang, Xiao-Dong Ding, Zhao-Rui Yang
Yuan-Shan Lu, Department of Laboratory, the First Affiliated People’s Hospital of Shanghai Jiao Tong University, Shanghai 200080, China
Jian-Gao Fan, Ji-Wei Fang, Xiao-Dong Ding, Department of Gastroenterology, the First Affiliated People’s Hospital of Shanghai Jiao Tong University, Shanghai 200080, China
Zhao-Rui Yang, Department of Pathology, the First Affiliated People’s Hospital of Shanghai Jiao Tong University, Shanghai 200080, China
Correspondence to: Yuan-Shan Lu, Department of Laboratory, the First Affiliated People’s Hospital of Shanghai Jiao Tong University, 85 Wujin Road, Hongkou District, Shanghai 200080, China. luyuanshan@126.com
Received: 2006-08-26 Accepted: 2006-09-20
AbstractAIM:To explore the relationship between hepatic stearoyl-CoA desaturase-1 (SCD-1) expression and adenosine triphosphate (ATP) content in nonalcoholic fatty liver caused by fat-rich diet.
METHODS:A total of 30 Sprague Dawley rats were divided into group A and B. The rats in group B were fed with fat-rich diet, consisting of 10% lard oil and 2% cholesterol, while those in group A served as controls. The rats were sacrificed at the 8th, 16th, and 24th week, respectively. The hepatic histological changes were evaluated by microscopy and transmission electron microcopy ......
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