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Therapeutic Hypothermia
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     This book is an excellent guide for any physician who transfuses blood, because it applies clinically relevant information to the decision to transfuse blood components. The book provides guidance for the clinical practice of blood-component therapy, and unlike standard blood-bank textbooks, it does not detail the scientific basis of blood groups and blood compatibility or the production and storage of blood components. I especially appreciated the thoughtful approaches to clinical problems by respected and talented colleagues in transfusion medicine. Their discussions gave me better ideas for taking care of patients, for helping me in my struggle to get physicians to use blood wisely, and for new approaches in teaching medical students, residents, and fellows about how interesting and important transfusion medicine can be.

    The book provides very good coverage of the use of blood components for hemolytic anemia, stem-cell transplantations, trauma and critical care, organ transplantations, coagulation disorders, neonates, and children. There are additional chapters about red-cell, granulocyte, and platelet transfusions and donor-derived lymphocyte infusions. In addition to standard blood components, other products are addressed, such as immune globulins, fibrin sealants, mononuclear cells, and growth factors.

    This second edition is more than 200 pages longer than the first edition, and better because of it. New chapters cover therapeutic apheresis, medical–legal issues, the administration of blood components, and the risks and benefits associated with transfusions. I am convinced that ABO-mismatched blood is erroneously given at least once every year in all medium-to-large hospitals, so I particularly welcome the new chapter on the administration of blood. This chapter provides an authoritative source for improving the bedside use of blood and reducing the risk of giving the wrong blood to the wrong patient — the leading cause of transfusion-related fatalities.

    I particularly enjoyed Walter H. Dzik's chapter, in which he critically assesses laboratory testing to guide the use of plasma transfusion before the placement of a central line and before percutaneous and endoscopic organ biopsies, thoracocentesis, lumbar puncture, and angiography. This chapter, which shows why the standard plasma-transfusion dose might correct an international normalized ratio of 3 but not of 1.3, will promote better use of plasma transfusions and avoid unneeded transfusions.

    The book has some minor errors and very poor black-and-white halftone reproductions of color photographs. It could have been improved by more illustrations and fewer of the very long tables such as the seven-page appendix on cancer-related anemia and erythropoietin. Despite these caveats, I encourage the use of this book by all physicians who are involved with the use of blood components.

    Ted Eastlund, M.D.

    University of Minnesota Medical School

    Minneapolis, MN 55455

    eastl002@umn.edu