摘要:目的 探讨血浆同型半胱氨酸(Hcy)水平与缺血性脑血管病的关系，并观察叶酸、维生素B 6 、维生素B 12 对Hcy的影响。 方法 对缺血性脑血管病患者123例(其中包括短暂性脑缺血发作47例，脑梗死76例)和正常对照组34例，采用高效液相色谱法测定空腹血浆Hcy浓度，并对高Hcy的58例患者进行叶酸、维生素B 6 、维生素B 12 治疗，2周后和6周后复查血浆Hcy浓度。 结果 ①脑梗死及TIA组血浆Hcy浓度显著高于正常对照组(P<0.05);脑梗死组血浆Hcy浓度显著高于TIA组(P<0.01)。②缺血性脑血管病患者血脂水平与Hcy水平无明显相关。③缺血性脑血管病患者血浆Hcy水平和血压呈正相关(r=0.44，P<0.05)。④用叶酸、维生素B 6 、维生素B 12 治疗，6周后血浆Hcy水平有明显下降。 结论 高同型半胱氨酸血症是缺血性脑血管病的独立危险因素，遗传和维生素B 6 、维生素B 12 、叶酸缺乏可能是其增高的重要因素。

    关键词:同型半胱氨酸;缺血性脑血管病;危险因素

    Study on the relationship between hyperhomocysteinemia and ischemnic cerebralvascular diseases.

    PAN Xiao-hua，GAO Wen-wei.

    (Baotou Railway Hospital，Baotou014040，Inner Mongolia，P.R.China)

    Abstract:Objective To study the relationship between serum homocysteine(Hcy)level and ischemic cerebrovascular disease. Methods The samples in this study were123patients with ischemic cerebrovascular disease and34normal controls.123pationts were divided into two groups.They were transient ischemic attack(47cases)and cerebral infarction(76cases).Fast serum Hcy con-centration was measured by high-performance liquid chromatography method. Results ①The mean serum homocysteine level was markedly higher in patients with cerebral infarction and TIA than in normal controls(P<0.05).Cerebral infarction group was markedly higher than TIA group(P<0.01).②There was no relationship between serum homocysteine level and plasma lipid level in patients with ischemic cerebrovascular disease.③We found positive correlation between arterial tension level and serum Hcy level(r=0.44 ......