高渗氯化钠溶液对急性失血性休克家兔血乳酸的影响 (pdf)

    【摘要】 目的 探讨高渗氯化钠溶液对急性失血性休克家兔血乳酸的影响,分析其对急性失血性休克的最佳救治效果。 方法 20只健康雌雄家兔经股动脉放血制备失血性休克模型，随机分为高渗氯化钠溶液和0.9%氯化钠溶液组两个治疗组，30min后分别按4ml/kg剂量5min内静脉输入高渗氯化钠溶液和0.9%氯化钠溶液， 测定休克前、休克30min及输液后30min、60min、90min时血乳酸(BL)变化水平。 结果 高渗氯化钠溶液组在输液后1h内均显著降低血乳酸(P<0.05)。 结论 高渗氯化钠溶液组较0.9%氯化钠溶液组更能显著降低血乳酸，提示急性失血性休克给予高渗氯化钠溶液早期救治具有较高的使用价值。

    【关键词】 高渗氯化钠溶液；失血性；血乳酸；休克

    Effects of hyperosmotic sodium chloride solution on blood lactate in rabbits with homorrhagic shock

    LI Xiao-ying， LI Yan，YE Teng-teng, et al.

    Undergraduate of Grade 3 Majoring in Clinical Medicine Youjiang Medical College for Nationalities Baise,Guangxi 533000,China

    【Abstract】 Objective To investigate the effects of hyperosmotic sodium chlorides solution (HSCS) on arterial blood lactate in rabbits with hemorrhagic shock ,and analysis the HSCS effects on hemorrhagic shock resuscitation. Methods Hemorrhagic shock models were induced in 20 male and female rabbits through artery. The animals were then randomly divided into 2groups :normal saline solution(0.9%NS) group, hyperosmotic sodium chloride solution(HSCS) group. 30minutes later, 0.9%NS and 7.5%HS 4ml/Kg were infused intravenously in 5minutes blood lactate(BL) were measured before shock, 30minutes after shock ,and 30min 、60min 、90min postinfusion. Results 7.5%HS group singnificantly reduced BL after 1 hour. Conclusion Compare with 0.9%NS, HSCS can more efficiently decreased BL, and more effective for hemorrhagic shock resuscitation. ......