[摘要] 目的 观察二甲双胍和吡格列酮对2型糖尿病(T2DM)患者降糖的疗效。方法 80例血糖控制不良的T2DM患者在原治疗方案下，随机分为2组：二甲双胍组，给予盐酸二甲双胍500 mg，2次/d，和模拟吡格列酮片2片，1次/d；吡格列酮组，给予吡格列酮30 mg，1次/d，和模拟二甲双胍片1片，2次/d。各组疗程均为12周。结果 2组在治疗后空腹血糖(FPG)、餐后2 h血糖(2hPG)和糖化血红蛋白(HbA1C)较用药前明显降低。用药8周和12周时，吡格列酮组比二甲双胍组2hPG下降更明显。结论 二甲双胍和吡格列酮均能有效地降低FPG、2hPG和HbA1C，在用药8~12周时，吡格列酮在降低2hPG方面优于二甲双胍组。

    [关键词] 2型糖尿病；二甲双胍；吡格列酮

    Effect of meformin and pioglitazone on reducing blood sugar of type 2 diabetes

    SU Yan，LIU Dian-xin.Endocrinology Department，Harbin First Hospital，Harbin 150010，China

    [Abstract] Objective To investigate the effect of meformin and pioglitazone on reducing blood sugar of T2DM patients.Methods 80 T2DM patients with less controlled blood sugar were divided into two groups; the patients in meformin group were treated with meformin HCl 500 mg ......