Impaired osteoblastic differentiation, reduced bone formation, and severe osteoporosis in noggin-overexpressing mice
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Original citation: J. Clin. Invest. 112:924–934 (2003). doi:10.1172/JCI200315543
Citation for this corrigendum: J. Clin. Invest. 115:1390 (2005). doi:10.1172/JCI200315543C1
During the preparation of this manuscript, errors were introduced into the Methods section, the legend of Figure 9, the corresponding text in the Results section, and the Acknowledgments.
The next to last sentence of Methods should be corrected to read:
"All in vitro and in vivo experiments were repeated at least three times except for the experiments reported in Figures 9b and 9c, which were repeated twice."
The next to last sentence in the legend to Figure 9 was incorrect. This sentence should read:
"(d and e) After culturing with 1 mM ascorbic acid-2-phosphate for 4 weeks, noggin and BMP-4 expression in bone marrow cell cultures of young and old mice (C57BL/6J) was analyzed by a combination of semiquantitative and real-time RT-PCR, while expression in SAM-R1 (R1) or SAM-P6 (P6) mice was analyzed by semiquantitative RT-PCR."
The fourth and second sentences before the end of the Results section were also incorrect. These sentences should read:
"In parallel, noggin mRNA levels in bone marrow cells isolated from SAM-P6 mice, measured by semiquantitative RT-PCR, were also significantly elevated (Figure 9d)." "Similar results were obtained using a combination of semiquantitative RT-PCR and real-time RT-PCR with bone marrow cell cultures isolated from aged 20-month-old C57BL/6 mice compared with 4-month-old adult mice (Figure 9e)."
The Acknowledgments should be corrected to read:
"This work was supported by Veterans Administration Merit Review Grants to E. Abe and M. Zaidi and by NIH grant AG-14197-08 to M. Zaidi."(Xue-Bin Wu, Yanan Li, Adi)
Citation for this corrigendum: J. Clin. Invest. 115:1390 (2005). doi:10.1172/JCI200315543C1
During the preparation of this manuscript, errors were introduced into the Methods section, the legend of Figure 9, the corresponding text in the Results section, and the Acknowledgments.
The next to last sentence of Methods should be corrected to read:
"All in vitro and in vivo experiments were repeated at least three times except for the experiments reported in Figures 9b and 9c, which were repeated twice."
The next to last sentence in the legend to Figure 9 was incorrect. This sentence should read:
"(d and e) After culturing with 1 mM ascorbic acid-2-phosphate for 4 weeks, noggin and BMP-4 expression in bone marrow cell cultures of young and old mice (C57BL/6J) was analyzed by a combination of semiquantitative and real-time RT-PCR, while expression in SAM-R1 (R1) or SAM-P6 (P6) mice was analyzed by semiquantitative RT-PCR."
The fourth and second sentences before the end of the Results section were also incorrect. These sentences should read:
"In parallel, noggin mRNA levels in bone marrow cells isolated from SAM-P6 mice, measured by semiquantitative RT-PCR, were also significantly elevated (Figure 9d)." "Similar results were obtained using a combination of semiquantitative RT-PCR and real-time RT-PCR with bone marrow cell cultures isolated from aged 20-month-old C57BL/6 mice compared with 4-month-old adult mice (Figure 9e)."
The Acknowledgments should be corrected to read:
"This work was supported by Veterans Administration Merit Review Grants to E. Abe and M. Zaidi and by NIH grant AG-14197-08 to M. Zaidi."(Xue-Bin Wu, Yanan Li, Adi)