[摘要]目的 研究服用丙戊酸的癫痫病人体质量的增加是否与血清胰岛素和瘦素水平的改变有关。方法选取28例未服用及24例服用丙戊酸的癫痫病人，应用放射免疫技术检测其空腹血清胰岛素和瘦素水平。结果丙戊酸组与对照组空腹血清胰岛素水平比较差异无显著性( t=-0.909，P >0.05)，但丙戊酸组肥胖病人的空腹血清胰岛素水平高于非肥胖者( t=-2.332，P <0.05)。丙戊酸组空腹血清瘦素水平高于对照组( t=-2.471，P < 0.05 )，丙戊酸组肥胖病人的空腹血清瘦素水平高于非肥胖病人( t=-2.221，P <0.05)。结论 丙戊酸对癫痫病人空腹血清胰岛素水平无明显影响，但可显著增加癫痫病人的空腹血清瘦素水平，尤其是肥胖病人。

    [关键词] 丙戊酸;癫痫;胰岛素;瘦素

    INFLUENCE OF VALPROATE ACID ON INSULIN AND LEPTIN LEVELS IN EPILEPTIC PATIENTS

    LU RUI-CHUN， TAN LAN， WANG YAN， et al

    (Department of Neurology， The Affiliated Hospital of Qingdao University Medical College， Qingdao 266003，China)

    [ABSTRACT]ObjectiveTo investigate whether changes of insulin and leptin levels had a role in the weight gain associated with valproate acid in epileptic patients. MethodsOf 52 epileptic patients， 24 received valproate acid monotherapy while 28 others did not .The serum insulin and leptin levels were measured by radioimmunoassay (RIA). ResultsThere was no statisti-cal difference between the mean fasting serum insulin level of the two groups ( t=-0.909 ......