physiological and biochemical data in model rats of congenital staª²tionary night blindness

    AN Jing£¬GUO Qun£¬GU Yongª²Hao£¬LI Li£¬YAN Guoª²Lin£¬ZHU Deª²Sheng£¬SHI Xinª²You£¬ZHANG Zuoª²Ming

    Department of Clinical Medicine, School of Aerospace Medicine, Fourth Military Medical University, Xi¬ðan 710033, China

    ¡¾Abstract¡¿ AIM: To determine the basic physiological and biochemical data in a natural occurring mutant rats of congenital stationary night blindness(CSNB). METHODS: Forty CSNB rats in F11 and F12 (20 female and 20 male) and 5 SD rats, aged from 13 to 15 weeks, were examined by electroretinogram (ERG) technique to evaluate the inherited traits under anaesthesia. The blood was then collected from the abdominal vein in torrefied tubes to measure the biochemical parameters. Then heart, liver, spleen, lung, brain (cerebrum, cerebellum, brain stem), pituitary, kidney, adrenal gland and testicle were taken to weigh. RESULTS: There were significant differences in organ weight between two sexes in CSNB rat (P<0.05), except for spleen,adrenal gland, pituitary. The coefficients of organs were significantly higher in female CSNB rats than that of the male except for kidney (P<0.01). The GLU, CHO, ALB were higher, and ALT, AST, ALP, BUN, CRE, TG, TP were lower in female rats; the result of electrolyte was that K, Na and iCa were higher in the male, Cl was higher in female, but there were no significant differences between female and male in statistics (P>0.05). CONCLUSION: The basic physiological and biochemical data of CSNB rat strain are in normal range. There are significant differences in some basic physiological and biochemical data between female and male CSNB rats, but not lots between CSNB rats and control SD rats. CSNB rat will become a new mutant model rat for researches on inherited retinal disease. ......