[摘要]目的 探讨肺栓塞的独立危险因素，明确每项危险因素所起作用大小。方法 放射性核素肺通气/灌注扫描和(或)螺旋CT检查并结合临床资料确诊的肺血栓栓塞症病人71例为病例组，性别、年龄匹配的部分住院病人及门诊健康体检者71例为对照组。详细记录文献上提及的相关危险因素，同时对部分因素进行了控制。两组入选者均查血常规，在空腹12 h后抽静脉血测血三酰甘油、胆固醇、抗凝血酶Ⅲ(AT-Ⅲ)、纤维蛋白原、纤溶酶原等生化指标，利用SPSS进行 t检验、χ2检验及Logistic回归分析。结果 肺栓塞的独立危险因素包括下肢静脉血栓形成( OR 44.427，95% CI 10.105～195.317， P <0.05)，手术( OR 3.407，95% CI 1.042～11.136， P < 0.05 )，纤维蛋白原( OR 1.717，95% CI 1.250～3.567， P <0.05)，胆固醇( OR 1.678，95% CI 1.287～3.672， P <0.05)，纤溶酶原( OR 1.022，95% CI 1.000～1.121， P <0.05)，吸烟指数( OR 1.003，95% CI 1.001～1.006， P <0.05)。结论下肢深静脉血栓形成、手术、高纤维蛋白原、胆固醇、纤溶酶原、吸烟是肺栓塞的独立危险因素，肺栓塞发病与多种因素有关。

    [关键词] 肺血栓栓塞症;危险因素;多因素分析

    ANALYSIS OF RISK FACTORS OF PULMONARY THROMBOEMBOLISM

    LI DA-GANG， SUN QIN-CHENG， CHENG ZHAO-ZHONG

    (Department Of Respiratory Diseases， The People's Hospital of Linyi， Linyi 276003， China)

    [ABSTRACT]ObjectiveTo identify independent risk factors of pulmonary thromboembolism and to estimate the risk of each factor. MethodsSeventy-one patients with pulmonary thromboembolism and 71 sex- and age-matched patients and healthy controls were recruited in this study. The diagnosis was confirmed by lung ventilation /perfusion scan and /or spiral CT as well as medical history. DVT was documented using ultrasonography or CT venography. Correlation risk factors mentioned in literatures were recorded in details and some factors were controlled. After fasting for 12 hours ......