摘要:目的 了解酵母样真菌耐药性变化趋势，探讨预防措施。 方法 对疑为深部真菌感染患者采样，用沙保罗培养基进行真菌分离，用VITEK-YBC鉴定卡作菌种鉴定，用ATB FUNGUS板进行药敏试验，并作统计分析。结果 真菌感染中以白色假丝酵母菌感染为主，占62.50%。真菌对两性霉素-B、5-氟胞嘧啶保持较高的体外抗真菌活性，敏感率分别为97.99%和97.10%，对制霉菌素的敏感率为87.95%，对酮康唑、益康唑的敏感率分别为70.09%和62.95%。 结论 深部真菌感染主要由白色假丝酵母菌、热带假丝酵母菌引起，对两性霉素-B、5-氟胞嘧啶保持较高的体外活性，两者仍是治疗真菌的有效药物。

    关键词:真菌;耐药性;预防

    Distribution of deep fungi detected and analysis of drug resistance.

    GAO Xia，LI Zhuo-cheng，LIUSong-yao.

    (Laborato-ry Department of Shenzhen Municipal Second People's Hospital，Shenzhen518035，Guangdong，P.R.China)

    Abstract:Objective Understand the developing trend of deep fungi to antibiotics and other anti-fungus drugs and provide sci-entific basis for formulating preventive and control measures. Methods Samples were taken from patients infected with fungi and Sobaurand's agar culture medium was used for separation of fungi.VITEK-YBC identified card was employed for identification of the fungi.And drug sensitivity test was carried out by using ATB FUNGUS stripes. Results The infection of Canadida albicans predominated ......