静脉滴注胺碘酮治疗急性冠脉综合征伴快速心房纤颤
冠脉综合征；心房颤动；胺碘酮,,冠脉综合征；心房颤动；胺碘酮,1资料与方法,2结果,3讨论,参考文献
【摘 要】 目的 观察静脉滴注胺碘酮对急性冠脉综合征(ACS)伴快速房颤患者的临床疗效。方法 32例ACS伴新近发生快速房颤患者，静脉应用胺碘酮，先静脉注射负荷量(75～100 mg)后，然后以0.5～1 mg/min静脉滴注维持，观察房颤转复、心室率控制及不良反应。结果 32例患者用药后15 min、2 h、24 h心室率分别是(135.8±12.5)次/min、(106.7±9.2)次/min、(84.4±14.0)次/min，较用药前(143.7±13.8)次/min明显下降(P<0.01)。其中25例患者(78.1%)在24 h内恢复窦性心率，2例出现窦性心动过缓，3例出现长RR间期，经停药或减量后恢复。结论 静脉应用胺碘酮治疗ACS伴快速房颤是有效及安全的。【关键词】 冠脉综合征；心房颤动；胺碘酮
Intravenous infusion of amiodarone for fast atrial fibrillation in patients with acute coronary artery syndrome
CUI Jizhi,FAN Lili,WANG Hongxia.
Department of Cardiology,The Second People's Hospital of Yinchuan City,Yinchuan 750011,China
【Abstract】 Objective To observe the effect of intravenous infusion of amiodarone on fast atrial fibrillation in patients with acute coronary artery syndrome(ACS).Methods After a load dose (75～100 mg) was given, intravenous infusion of amiodarone (0.5～1 mg/min) was administered continuously in 32 ACS patients whose fast atrial fibrillation took place recently. The reversion of atrial fibrillation, the controlled heart rhythm and the side effect of amiodarone were observed.Results The heart beat rates at 15 min,2 hour,24 hour after the administration of amiodarone in the 32 patients were (135.8±12.5) beats/min, (106.7±9.2) beats/min, (84.4±14.0) beats/min respectively,significantly lowered than the rate (143.7±13.8)beats/min before treatment (P<0.01). Atrial fibrillation was reverted to sinus rhythm within 24 hour in 25 of 32 case (78.1%).Sinus bradycardia was occurred in 2 patients, and prolongation of RR intermitment was observed in 3 patients,but cardiac rhythm in all the patients returned to normal after reducing the dose or ceasing the medicine.Conclusion Intravenous infusion of amiodarone is effective and safe in the treatment of fast atrial fibrillation in patients with ACS. ......
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