泮托拉唑治疗消化性溃疡合并上消化道出血的临床观察 (pdf)

    【摘要】 目的 研究泮托拉唑钠冻干粉剂注射剂对消化性溃疡合并上消化道出血的疗效。 方法 回顾分析我院2003～2005年间收治的87例经内镜证实的消化性溃疡合并上消化道出血患者随机分为两组，其中泮托拉唑治疗组56例，奥美拉唑治疗组31例。分别以泮托拉唑及奥美拉唑40mg静滴每日2次。 结果 泮托拉唑组52例(92.86%)于4天内止血,疗效判断为显效；4例(7.14%)于6天内止血，疗效判断为有效；无效0例，总有效率达100%。奥美拉唑组于4天内止血的患者29例(93.55%), 疗效判断为显效；2例(6.45%)于6天内止血，疗效判断为有效；无效0例，总有效达100%。两组在治疗方面其显效率及有效率方面差异均无显著性(P>0.05)。结论 泮托拉唑是治疗消化性溃疡合并上消化道出血的有效药物。

    【关键词】 消化性溃疡；上消化道出血；泮托拉唑

    A clinical study on intravenous pantoprazole for the management of peptic ulcer complicating with upper digestive tract bleeding

    MIAO Tong-yun, JING Xiao-jing, WANG Gang, et al. Department of Internal Medicine, Shizuishan Central Hospital, Huinong District Ningxia 753200, China

    【Abstract】 Objective To investigate the effect of intravenous pantoprazole for the management of peptic ulcer bleeding.Methods Clinical data were retrospectively analyzed in 78 patients admitted to Shi Zuishan Central Hospital from 2003to 2005. These patients with endoscopic proved pepetic ulcer bleeding were randomized divided into two groups. Fifty-six cases were classified into pantoprazole group and 31 cases into omeprazole group,and they were given intravenous pantoprazole or omeprazole 40mg twice daily.Results In pantoprazole group,the peptic ulcer bleeding in 52 cases(92.86P%)stopped in 4 days, 4cases(7.14%)in 6days, while in omeprazole group, the bleeding in 29 cases(93.55%) stopped in 4 days, 2 cases(6.45%) in 6 days. The total effective rate for controlling peptic ulcer bleeding were both 100%in two groups, there no significant differences between two groups(P>0.05).Conclusion Intravenous pantoprazole is effective in the management of peptic ulcer bleeding. ......