通心络对不稳定型心绞痛患者细胞间粘附分子1水平的影响
肌病,肌病,通心络;冠状动脉疾病;不稳定型心绞痛;细胞间粘附分子1,,肌病,肌病,通心络;冠状动脉疾病;不稳定型心绞痛;细胞间粘附分子1,通心络对不稳定型心绞痛患者细胞间粘附分子1水平的影
【摘 要】 目的 观察通心络对不稳定型心绞痛患者血清可溶性细胞间粘附分子1(sICAM1)水平的影响,探讨其治疗动脉粥样硬化性疾病的可能机制。方法 将60例不稳定型心绞痛患者随机分为常规治疗组(30例)和通心络组(30例),常规治疗组予常规治疗,通心络组在常规治疗的基础上加用通心络。监测治疗前后血清 sICAM1和血浆血脂水平的变化。结果 2组治疗后血浆总胆固醇(TC)和低密度脂蛋白(LDL)水平均较治疗前明显下降(P<0.05),但2组间比较差异无显著意义;通心络组血清sICAM1浓度由治疗前的(129.37±32.29)ng/ml下降到治疗后的(78.42±26.42)ng/ml,常规治疗组血清sICAM1浓度由治疗前的(122.32±36.12)ng/ml下降到治疗后的(89.24±21.25)ng/ml,治疗后均有明显降低,且治疗后通心络组sICAM1水平明显低于同期常规治疗组(均P<0.05)。结论 通心络能明显降低不稳定型心绞痛患者血清sICAM1含量,具有抑制动脉血管壁炎症、保护血管内皮细胞的作用。【关键词】 肌病,肌病,通心络;冠状动脉疾病;不稳定型心绞痛;细胞间粘附分子1
Effect of Tongxinluo capsule on intercellular adhesion molecule-1 in patients with unstable angina pectoris
YE Dahua,XIE Yiqin.
Longchuan County Hospital of Traditional Chinese Medicine,Guangdong Province,Longchuan 517300,China
【Abstract】 Objective To observe the effect of Tongxinluo on soluble intercellular adhesion molecule-1 in patients with unstable angina pectoris.Methods 60 cases with unstable angina pectoris were randomly divided into treatment group(routine treatment added Tongxinluo) and control group (routine treatment).Before and after 1 month's treatment,sICAM1 in serum and blood lipids were measured.Results After treatment ......
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