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编号:11359268
幽门螺杆菌与DNA错配修复系统
http://www.100md.com 吴 莹, 姜 政
错配修复;微卫星不稳定;幽门螺杆菌;突变;肿瘤,吴莹,姜政,通讯作者:,RelationshipbetweenHelicobacterpyloriandDNAmismatchrepairsystem,YingWu,ZhengJiang,Correspond
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     吴莹, 姜政, 重庆医科大学附属第一医院消化科 重庆市 400016

    通讯作者:
姜政, 400016, 重庆市, 重庆医科大学附属第一医院消化科. jianggooddoctor@mail.china.com

    电话: 023-68891218

    收稿日期: 2006-09-29 接受日期: 2006-10-18

    Relationship between Helicobacter pylori and DNA mismatch repair system

    
Ying Wu, Zheng Jiang

    Ying Wu, Zheng Jiang,
Department of Gastroenterology, the First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China

    Correspondence to:
Zheng Jiang, Department of Gastroenterology, the First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China. jianggooddoctor@mail.china.com

    Received:
2006-09-29 Accepted:2006-10-18

    Abstract

    Helicobacter pylori infection causes the defect of mismatch repair (MMR) in eucaryotes, and microsatellite instability (MSI) in gastric epithelial cells, which increases the spontaneous mutation of relative genes, and finally results in the susceptibility to tumors in human bodies. DNA MMR can prevent the excessive proliferation of mutant cells and development of tumors by correcting mismatched bases, which occur in the process of duplication and recombination, and inducing apoptosis of the cells in which DNA had been seriously impaired. The majority of the mutation in mismatch repair gene is the gene mutation in which substitution exceeds the absence or insertion of the single basic group. In MMR, hMLH1 and hMSH2 gene are the main controlling genes. Current research showed that H pylori infection might lead to functional defect of MMR, which had played an important role in the development of gastric carcinomas. In this article, we reviewed the correlations between H pylori infection and DNA mismatch repair system.

    Key Words: Mismatch repair; Microsatellite instability; Helicobacter pylori; Mutation; Tumor

    Wu Y, Jiang Z. Relationship between Helicobacter pylori and DNA mismatch repair system. Shijie Huaren Xiaohua Zazhi 2007;15(1):51-55 ......

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