肠易激综合征精神心理因素、肠黏膜肥大细胞及5-羟色胺的变化
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陈文科, 邹益友, 李富军, 罗 丹
肠易激综合征;发病机制;心理因素;肥大细胞;5-羟色胺,陈文科,邹益友,李富军,罗丹,陈文科,通讯作者:,Changesofpsychosocialfactors,entericmucosalmastcellsand5-h
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陈文科, 北京大学深圳医院消化内科 广东省深圳市 518036
邹益友, 李富军, 中南大学湘雅医院消化内科 湖南省长沙市 410078
罗丹, 江门市中心医院消化内科 广东省江门市 529030
陈文科, 2005年中南大学湘雅医院硕士, 医师.
通讯作者: 邹益友, 410078, 湖南省长沙市, 中南大学湘雅医院消化内科. zouyiyou1957@163.com
电话: 0731-4327106 传真: 0731-4327348
收稿日期: 2006-10-09 接受日期: 2006-10-25
Changes of psychosocial factors, enteric mucosal mast cells and 5-hydroxytryptamine in irritable bowel syndrome
Wen-Ke Chen, Yi-You Zou, Fu-Jun Li, Dan Luo
Wen-Ke Chen,Department of Gastroenterology, Shenzhen Hospital of Beijing University, Shenzhen 518036, Guangdong Province, China
Yi-You Zou, Fu-Jun Li,Department of Gastroenterology, Xiangya Hospital of Central South University, Changsha 410078, Hunan Province, China
Dan Luo,Department of Gastroenterology, Central Hospital of Jiangmen City, Jiangmen 529030, Guangdong Province, China
Correspondence to:Yi-You Zou, Department of Gastroenterology, Xiangya Hospital of Central South University, Changsha 410078, Hunan Province, China. zouyiyou1957@163.con
Received:2006-10-09 Accepted:2006-10-25
Abstract
AIM: To explore the roles of psychosocial factors, enteric mucosal mast cells (MC) and 5-hydroxytryptamine (5-HT) in the pathogenesis of irritable bowel syndrome (IBS).
METHODS: Hamilton anxiety scale (HAMA) and Hamilton depression scale (HAMD) were used to evaluate the psychosocial status of 27 IBS patients and controls. Immunohistochemistry was used to examine the number of mucosal MC in ileocecal junction (ICJ), and the content of mucosal 5-HT in ICJ was detected by high-performance liquid chromatography (HPLC) with an electrochemical detector. The relationship among the scores of HAMA and HAMD, the number of MC and the concentration of 5-HT were analyzed.
RESULTS: The scores of HAMA (18.26 ± 6.23) and HAMD (20.93 ± 6.96) in IBS patients were significantly higher than those in the controls (9 ......
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