Application of immunosuppressant protocol with low concentration of cyclosporine A in patients having underwent renal transplantation

    MIAO Shuª²Zhai, L¦a Yuª²Tao, CAI Wenª²Li£¬QU Qingª²Shan

    Department of Organ Transplantation, Fifth People¬ðs Hospital of Zhengzhou City, Zhengzhou 450003, China

    ¡¾Abstract¡¿ AIM: To evaluate the outcomes of application of immunosuppressant protocol with low concentration of cyclosporine A (CsA) in patients who have underwent renal transplantation. METHODS: Totally 133 patients having underwent renal transplantation were included in this study. They were divided into 3 groups according to different doses of mycophenolate mofetil (MMF) and different concentrations of CsA: high concentration of CsA and high dose of MMF; high concentration of CsA and low dose of MMF; low concentration of CsA and high dose of MMF. Differences among the groups were analyzed. RESULTS: Administration of immunosuppressant with low concentration of CsA and high dose of MMF brought out the lower incidences of infection, disorder of metabolism and other side effects than the other 2 groups did, whereas there was no significant difference in incidence of rejection among these groups. CONCLUSION: Administration of low concentration of CsA and high dose of MMF in the immunosuppressant protocol should be applied in clinical renal transplantation in order to reduce the occurrences of side effects of CsA as the rejection is suppressed. ......