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编号:11340915
老年性痴呆病人载脂蛋白E基因多态性与淀粉样 β蛋白前体表达的关系
http://www.100md.com 《齐鲁医学杂志》 2006年第4期
阿尔茨海默病;载脂蛋白E类;多态性,单核苷酸;淀粉样β蛋白前体,,],阿尔茨海默病;载脂蛋白E类;多态性,单核苷酸;淀粉样β蛋白前体,老年性痴呆病人载脂蛋白E基因多态性与淀粉样β蛋白前体表达的关
     [摘要]目的 探讨老年性痴呆(AD)病人载脂蛋白E(apoE)基因多态性与淀粉样β蛋白前体16-17外显子(App16-17)表达之间的关系。方法 应用聚合酶链反应-限制性片段长度多态性(PCR-RFLP)技术,检测25例AD病人及25例健康老年人的apoE基因型,同时应用相对定量的竞争RNA扩增聚合酶链反应(RT-PCR)技术,检测上述病人外周血单个核细胞中App16-17表达量。结果 AD组病人apoE ε4等位基因频率较对照组升高( χ 2 = 8.67 ,P <0.01),apoE ε4等位基因携带者App16-17表达量较ε2、ε3等位基因携带者高,但差异无显著性。结论apoE ε4基因为老年性 痴呆的危险因子,apoE ε4等位基因对AD病人的App16-17表达量无显著影响。

    [关键词] 阿尔茨海默病;载脂蛋白E类;多态性,单核苷酸;淀粉样β蛋白前体

    A CORRELATION BETWEEN APOLIPOPROTEIN E POLYMORPHISM AND β AMYLOID PRECURSOR PROTEIN IN PATIENTS WITH ALZHEIMER DISEASE

    ZHANG WEI, TAN LAN, JIANG SAN-DUO

    (Department of Emergency, East Campus of Qingdao Municipal Medical Group, Qingdao 266071, China)

    [ABSTRACT]ObjectiveTo explore the relationship between the expressions of apolipoprotein E (apoE) gene polymor-phism and β amyloid precursor protein (16-17exons) in Alzheimer disease (AD). MethodsThe polymerase chain reaction-re-striction fragment length polymorphism (PCR-RFLP) was used to detect apoE genetype in 25 AD patients and 25 healthy age-matched controls. Meanwhile, The expression of β amyloid precursor protein 16-17exons (App16-17) in peripheral mononuclear blood cells were examined using quantitive competitive RT-PCR methods. ResultsThe increased frequency of apoE ε4 allele ( χ2 = 8.67 ......

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