[摘要]目的 探讨乙酰肝素酶(Hpa)在子宫内膜癌中的表达及其与肿瘤临床病理学特征的关系。方法 采用免疫组化PV6000法检测60例子宫内膜癌组织中Hpa的表达。结果 Hpa在子宫内膜癌组织中的阳性表达率为65.0%(39/60)，其表达与子宫内膜癌的组织学病理分级、临床手术分期、肌层浸润深度和淋巴结转移有关( χ2 =4.40～7.33，P <0.05)。结论 Hpa在子宫内膜癌的进展中起重要作用，可作为判断子宫内膜癌生物学行为的有用指标。

    [关键词] 子宫内膜肿瘤;乙酰肝素酶;病理学，临床

    RELATIONSHIP BETWEEN HEPARANASE EXPRESSION AND CLINICOPATHOLOGIC FEATURES OF ENDOMETRIAL CARCI-NOMA

    WANG LIN

    (Department of Obstetrics and Gynecology， Qingdao Central Hospital， Qingdao 266042， China)

    [ABSTRACT]ObjectiveTo study the expression of heparanase (Hpa) in carcinoma of endometrium and the relation with its clinical pathological characteristics. MethodsThe expression of Hpa was detected by immunohistochemistry PV6000 me- thod in 60 cases of endometrial carcinoma. ResultsThe positive Hpa expression of the carcinoma was 65.0% ......