法西多曲；胡椒醛；胡椒丙烯酸；合成_

胡椒丙烯酸的合成研究

http://www.100md.com 《咸宁学院学报(医学版)》 2006年第5期

法西多曲；胡椒醛；胡椒丙烯酸；合成,,法西多曲；胡椒醛；胡椒丙烯酸；合成,1材料与方法,2结果,3讨论,参考文献：

     摘要：目的研究胡椒丙烯合成方法。方法采用胡椒醛与丙二酸二乙酯Knoevenagel缩合、催化氢化、水解和Mannich反应并脱羧得胡椒丙烯酸，并对其制备工艺进行优化。结果总收率81 %。结论采用该方法制备胡椒丙烯酸值得进一步探讨。

    关键词：法西多曲；胡椒醛；胡椒丙烯酸；合成

    The Synthesis of Piperonylacrylic Acid

    ZHOU Heping，CHEN Xiaoyong，TAN Lijun

    (Pharmic School of Xianning College,Xianning Hubei 437100,China)

    ABSTRACT:Objective To study the synthetic method of piperonylacrylic acide.Methods The synthesis was accomplished through the Knoevenagel reaction,catalytic hydrogenation,hydrolysis and Mannich reaction of piperonal and dietlyle malonate.Results The overall yield rate of 81% was achived.Conclusion This method is worthy to be farther explored and studied.KEY WORDS：Fasidotril;Piperonal; Piperonylacrylic acid;Synthesis 胡椒丙烯酸(piperonylacrylic acid 1)是血管紧张素转化酶(ACE)和肽链内切酶(NEP)双重抑制剂法西多曲(Fasidotril)的关键中间体 ......

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