Author's Response to Dr. Leo
http://www.100md.com
《科学公立图书馆医学》
University of North Carolina, Chapel Hill, North Carolina, United States of America
Jonathan Leo raises issues with the adoption literature on schizophrenia [1]. These studies were intensively and independently scrutinized in the 1980s—see the series of papers by Kendler and Gruenberg (e.g., [2]). Most would agree that the number, size, and quality of adoption studies do not provide the highest-quality data (as discussed at more length elsewhere [3].
However, the salient point in my paper [4] was that this body of work (twin, adoption, and family studies) provides a consistent and solid rationale for the search for genes for schizophrenia.
Dr. Leo's comments about the treatment of schizophrenia are not within the scope of my paper.
References
Leo J (2006) Schizophrenia adoption studies. PLoS Med 3: e366–DOI: 10.1371/journal.pmed.0030366 DOI: 10.1371/journal.pmed.0030366.
Kendler KS, Gruenberg AM (1984) An independent analysis of the Danish Adoption Study of Schizophrenia. VI. The relationship between psychiatric disorders as defined by DSM-III in the relatives and adoptees. Arch Gen Psychiatry 41: 555–564.
Sullivan PF, Owen MJ, O'Donovan MC, Freedman RR, (2005) Genetics. In: Lieberman J, Stroup T, Perkins D, editors. Textbook of schizophrenia Washington (D. C.): American Psychiatric Publishing.
Sullivan PF (2005) The genetics of schizophrenia. PLoS Med 2: e212–DOI: 10.1371/journal.pmed.0020212 DOI: 10.1371/journal.pmed.0020212.(Patrick Sullivan)
Jonathan Leo raises issues with the adoption literature on schizophrenia [1]. These studies were intensively and independently scrutinized in the 1980s—see the series of papers by Kendler and Gruenberg (e.g., [2]). Most would agree that the number, size, and quality of adoption studies do not provide the highest-quality data (as discussed at more length elsewhere [3].
However, the salient point in my paper [4] was that this body of work (twin, adoption, and family studies) provides a consistent and solid rationale for the search for genes for schizophrenia.
Dr. Leo's comments about the treatment of schizophrenia are not within the scope of my paper.
References
Leo J (2006) Schizophrenia adoption studies. PLoS Med 3: e366–DOI: 10.1371/journal.pmed.0030366 DOI: 10.1371/journal.pmed.0030366.
Kendler KS, Gruenberg AM (1984) An independent analysis of the Danish Adoption Study of Schizophrenia. VI. The relationship between psychiatric disorders as defined by DSM-III in the relatives and adoptees. Arch Gen Psychiatry 41: 555–564.
Sullivan PF, Owen MJ, O'Donovan MC, Freedman RR, (2005) Genetics. In: Lieberman J, Stroup T, Perkins D, editors. Textbook of schizophrenia Washington (D. C.): American Psychiatric Publishing.
Sullivan PF (2005) The genetics of schizophrenia. PLoS Med 2: e212–DOI: 10.1371/journal.pmed.0020212 DOI: 10.1371/journal.pmed.0020212.(Patrick Sullivan)