参麦注射液对急性心肌梗死大鼠心室重构的影响
参麦注射液；急性心肌梗死；心室重构,,参麦注射液；急性心肌梗死；心室重构,1材料和方法,2结果,3讨论,参考文献
【摘要】 目的：探讨参麦注射液对急性心肌梗死(AMI)大鼠心室重构的影响。方法：通过结扎冠状动脉前降支建立AMI模型大鼠，AMI后24h存活的48只大鼠随机分为四组：AMI后1周模型组；AMI后参麦注射液治疗1周组；AMI后2周模型组；AMI后参麦注射液治疗2周组。另设1周、2周假手术组各8只。治疗组每日腹腔注射参麦注射液1次，AMI模型组和假手术组大鼠腹腔注射等量的生理盐水。测量各组心室重构参数。结果：与假手术组比较，AMI后1周时，心室腔已明显扩大(P<005)；到梗死后2周时，心室腔内径扩大更明显，与假手术组相比有显著性差异(P<001)，且心室重量指数(VWI)比假手术组明显增加(P<005)。参麦注射液治疗2周后可改善心梗后心室重量指数增加、心室腔扩大的病理变化(P<005)。结论：参麦注射液能改善大鼠AMI后心室重构。【关键词】 参麦注射液；急性心肌梗死；心室重构
Effects of Shenmai Injection on Ventricular Remodeling
after Acute Myocardial Infarction in Rats
WEN Xiaojing, CHEN Yanjing, LI Jiandong, et al
Department of Physiology, Hebei North University, Zhangjiakou, 075000, Hebei, China
【ABSTRACT】 Objective: To investigate the effects of Shenmai injection on ventricular remodeling after acute myocardial infarction(AMI) in rats. Methods: AMI was established by ligating the anterior descending coronary artery in male SD rats. Twentyfour hours after the procedure, the 48 surviving rats were seperated randomly into AMI one week group、 AMI twoweek group、Shenmai injection treatment oneweek and twoweek groups (n=12). Oneweek shamoperated and twoweek shamoperated groups were taken randomly as noninfarction control. After treated with the drug and placebo by intraperitoneal injection(IP), the ventricular remodeling of oneweek and twoweek groups was assessed. Results: Compared with shamoperated group, left ventricular diameter(LVD) was increased significantly in AMI group after a week(P<005)；LVD and ventricular weight index(VWI) were all increased significantly(P<005 or 001)in AMI group after two weeks. In comparison with AMI group, LVD and VWI were all decreased significantly in Shenmai injection treatment group after two weeks(P<005). Conclusion: Shenmai injection can prevent left ventricular remodeling after AMI in rats. ......
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