摘要:目的 观察压力超负荷心肌肥大大鼠的体视学变化，探讨血管紧张素受体拮抗剂芦沙坦(Los)在压力超负荷心肌肥大反应过程中的作用。 方法 建立腹主动脉缩窄性高血压大鼠模型，测定大鼠平均动脉压(MAP)、大鼠心肌的表面积密度(SV)、体积密度(VV)、比表面(S/V)及平均自由程(λ)等各项体视学参数并计算。 结果 COA大鼠的MAP明显增高，心肌横断面积及平均直径明显增大，SV、VV、S/V及λ等与对照组相比均有显著性差异;COA+Los组的MAP值大致恢复至正常水平，心肌横断面积、平均直径及SV、、VV等明显小于COA组，S/V及λ则增大。 结论 Los可明显改变体视学各项参数，对压力超负荷引起的高血压和心肌肥大具有明显逆转的作用。

    关键词:心肌肥大;体视学;芦沙坦;大鼠

    Quantitative analysis of the role of losartan in myocardial hypertrophy caused by overload pressure in rats.

    ZHONG Nan-Tian，FU Shi-Gan，FU Jiao-Rong，et al.

    (Department of Histology and Embryology，Hainan Medical College，Haikou571101，Hainan，P.R.China)

    Abstract:Objective To analyze the role of angiotensionⅡtype1receptor antagionist losartan(Los)in the myocardial hypertro-phy rats caused by pressure overload during investigating the change of stereological data. Methods The coarctation of the abdomi-nal aorta(COA)hypertension model was established in Sprague-Dawley rats.The mean arterial pressure(MAP)were measured in each rat.the stereological parameters such as the myocardial surface density、the myocardial volume density、the myocardial specific surface and the mean free path etc.were measured and numerated. Results The MAP of COA rats was significantly increased ......