褪黑素对大鼠应激性胃粘膜损伤的保护作用及其机理
褪黑素；侧脑室；应激性胃溃疡,,褪黑素；侧脑室；应激性胃溃疡,1材料与方法,2结果,3讨论,参考文献：
摘要：目的 探讨中枢褪黑素(MT)对大鼠应激性胃粘膜损伤的保护作用及其机制。方法 采用束缚冷应激复制大鼠应激性溃疡模型，通过脑立体定位仪进行侧脑室注射，检测各组大鼠胃溃疡指数(UI)、胃粘膜血流量(GMBF)、胃液量和胃液酸度。结果 与正常组比较，应激组UI增大，GMBF下降，胃液量和胃液酸度升高(P<0.05，P<0.01)。MT+应激组UI减小，GMBF增多，胃液量和胃液酸度降低， 与应激组和生理盐水(NS)+应激组比较差异有显著性，P<0.05、P<0.01。结论 中枢MT对胃粘膜损伤有保护作用，其机制与增加胃粘膜血流量及抑制胃酸分泌有关。关键词：褪黑素；侧脑室；应激性胃溃疡
The Protective Role of Melatonin on Stress Gastric MucosaInjUry in Rat and Its Mechanism
HUANG Bilan，WANG Qiugui，Yu Liangzhu,et al
(Department of Physiology,Xianning College，Xianning Hubei 437100，China)
ABSTRACT:Objective To investigate the protective role of central melatonin(MT) in stress gastric mucosa injury in rats and its mechanism.Methods The stress ulcer model was established by constraintcold stress method.The drugs were injected into lateral ventricle of cerebrum by the brain stereotaxic frame.The ulcer index(UI) ......
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