【摘 要】 目的 探讨经皮冠状动脉介入治疗(PCI)前后血小板CD41、CD62p变化及其临床意义。 方法 98例行PCI的患者分为不稳定型心绞痛组(50例)和稳定型心绞痛组(48例)。对照组40例为冠状动脉造影正常患者。流式细胞仪测定血小板CD41、CD62p的表达。 结果 CD41、CD62p水平在PCI术后即刻较术前有显著性下降，随后逐渐升高，术后4h达到峰值。不稳定心绞痛组CD41、CD62p在术前及峰值水平均较稳定组显著升高。对照组患者CD41、CD62p水平在冠状动脉造影前后无显著性变化。 结论 血小板活性在PCI前后有动态改变，血小板激活状态与斑块稳定性密切相关。

    【关键词】 冠心病;经皮冠状动脉介入治疗;CD41;CD62p

    Expression of Platelet Surface Glycoprotein CD41and CD62p in Patients with Coronary Heart Disease Treated by Percutaneous Coro-nary Intervention LI Junyong ，SUN Zhimin，QI Xiaoyong，et al.

    * Department of internal medicine，Bethune Military Medical College，Shiji-azhuang050081，China

    【Abstract】 Objective To study CD41and CD62p changes and their clinical significance in patients with coronary heart disease(CHD)who were treated with percutaneous coronary intervention(PCI).Methods The study group was comprised of98consecutive patients who under-went PCI ......