肿瘤M2型丙酮酸激酶在结直肠癌粪便筛查中的临床价值
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张 波, 陈剑英, 王国斌
肿瘤M2丙酮酸激酶;粪便筛查;结肠癌张波,陈剑英,王国斌.肿瘤M2型丙酮酸激酶在结直肠癌粪便筛查中的临床价值. 世界华人消化杂志2007;15(2)193-196 结肠癌患者与健康对照TumorM2-PK水平比较的统计值表2 不同分期结肠癌患者TumorM2-PK
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张波, 陈剑英, 王国斌, 华中科技大学同济医学院附属协和医院普外科 湖北省武汉市 430022
通讯作者: 张波, 430022, 湖北省武汉市解放大道1277号, 华中科技大学同济医学院附属协和医院普外科.
unionzhang@yahoo.com
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收稿日期: 2006-10-15 接受日期: 2006-11-10
Value of fecal tumor M2 pyruvate kinase in diagnosis of colorectal cancer
Bo Zhang, Jian-Ying Chen, Guo-Bin Wang
Bo Zhang, Jian-Ying Chen, Guo-Bin Wang, Department of General Surgery, Union Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, Hubei Province, China
Correspondence to: Bo Zhang, Department of General Surgery, Union Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, Hubei Province, China. unionzhang@yahoo.com
Received: 2006-10-15 Accepted: 2006-11-10
AbstractAIM: To evaluate the value of fecal M2 pyruvate kinase (M2-PK) as a screening biomarker for colorectal cancer.
METHODS: The tumor fecal M2-PK was determined by enzyme-linked immunosorbent assay (ELISA) in colorectal cancer patients (n = 80) and healthy controls (n = 80), and the results were comparatively analyzed.
RESULTS: The cut-off value to discriminate patients from controls was established at 166.7 mkat/L for tumor M2-PK. The mean level of fecal tumor M2-PK was significantly higher in colorectal cancer patients than that in the normal controls (713.41 mkat/Lvs 59.55 mkat/L, P < 0.0001), and the overall sensitivity and specificity were 77.5% and 92.5%, respectively. With the progression of colorectal carcinoma, the level of tumor M2-PK as well as the sensitivity was increased (F = 52.984,P < 0.0001). In patients with Dukes A (n = 11), B (n = 37), C (n = 25), and D (n = 7) stages, the mean levels of tumor M2-PK were 233.53, 522.58, 847.27 and 1998 ......
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