江苏汉族人群p53第7内含子多态性与慢性萎缩性胃炎无相关性
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王剑蓉, 赖仁胜, 张心海, 谢 玲
慢性萎缩性胃炎;p53基因;多态性;内含子;测序王剑蓉,赖仁胜,张心海,谢玲.江苏汉族人群p53第7内含子多态性与慢性萎缩性胃炎无相关性. 世界华人消化杂志2007;15(2)171-175,王剑蓉,赖仁胜,谢玲,张心海
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王剑蓉, 南京中医药大学基础医学院, 南京中医药大学附属医院病理科, 国家中管局三级分子生物学实验室 江苏省南京市 210029
赖仁胜, 谢玲, 南京中医药大学附属医院病理科, 国家中管局三级分子生物学实验室 江苏省南京市 210029
张心海, 南京中医药大学 江苏省南京市 210029
通讯作者: 赖仁胜, 210029, 江苏省南京市汉中路155号, 南京中医药大学附属医院病理科. lairensheng@163.com
电话: 025-86617141-70309
收稿日期: 2006-10-10 接受日期: 2006-10-25
No association between p53 gene intron 7 polymorphism and chronic atrophic gastritis in Han Chinese of Jiangsu province
Jian-Rong Wang, Ren-Sheng Lai, Xin-Hai Zhang, Ling Xie
Jian-Rong Wang, Basic Medical College, Nanjing University of Traditional Chinese Medicine; Department of Pathology, the Affiliated Hospital of Nanjing University of Traditional Chinese Medicine; the Third-Grade Laboratory of Molecular Biology, State Administration of Traditional Chinese Medicine, Nanjing 210029, Jiangsu Province, China
Ren-Sheng Lai, Ling Xie, Department of Pathology, the Affiliated Hospital of Nanjing University of Traditional Chinese Medicine; the Third-Grade Laboratory of Molecular Biology, State Administration of Traditional Chinese Medicine. Nanjing 210029, Jiangsu Province, China
Xin-Hai Zhang, Nanjing University of Traditional Chinese Medicine, Nanjing 210029, Jiangsu Province, China
Correspondence to: Ren-Sheng Lai, Department of Pathology, the Affiliated Hospital of Nanjing University of Traditional Chinese Medicine, 155 Hanzhong Road, Nanjing 210029, Jiangsu Province,China. lairensheng@163.com
Received: 2006-10-10 Accepted: 2006-10-25
AbstractAIM: To explore whether the polymorphism of p53 gene intron 7 is associated with the occurrence of chronic atrophic gastritis (CAG) in Han Chinese of Jiangsu province.
METHODS: The genome DNA was extracted from tissues of 80 CAG patients and 76 healthy controls, and the exon 7 and 8 as well as the intron 7 within exon 7 and 8 of p53 gene were amplified by polymerase chain reaction (PCR) ......
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