天麻素在大鼠小肠内吸收动力学的研究
http://www.100md.com
| 第1页 |
参见附件(121KB，5页)。
李 丁，于飞千，孙天慧，杨星钢，潘卫三
(沈阳药科大学 药学院，辽宁 沈阳 110016)
摘 要：目的 研究天麻素在大鼠小肠内的吸收行为。方法 采用大鼠在体循环方法研究天麻素在不同浓度和不同肠段下的吸收。结果 在10.0～200.0 mg·L-1的质量浓度时，天麻素在小肠各段的吸收量与浓度呈线性关系，ka值基本保持不变，各肠段的吸收速率无显著性差异。在十二指肠、空肠和回肠的ka值分别为(0.143 ±0.044) h-1, (0.155 ±0.058) h-1, (0.129 ±0.038) h-1；与其他肠段相比，天麻素在结肠部位的吸收显著降低，ka值为(0.010 ±0.003) h-1。结论 天麻素在肠道的吸收呈现一级动力学过程，吸收机制为被动扩散，它在小肠上中部的吸收情况较好。
关键词：药剂学；药物动力学；在体循环；肠吸收；天麻素
中图分类号：R94 文献标识码：A
contents
Absorption kinetics of gastrodin in intestine of rats
LI Ding, YU Fei-qian, SUN Tian-hui, YANG Xing-gang, PAN Wei-san
(School of Pharmacy, Shenyang Pharmaceutical University ,Shenyang 110016,China)
Abstract: Objective To study the absorption kinetics of gastrodin at different intestinal sections in rats and the influence of drug concentration on it. Method The intestines in rats were cannulated for in situ recirculation. Gastrodin concentrations in the perfusate were measured by reversed phase HPLC. Result When the concentration of gastrodin raised from 10 to 200 mg·L-1, the uptake of gastrodin increased linearly. The concentration of gastrodin had no effects on the permeability coefficient ......
您现在查看是摘要介绍页，详见PDF附件(121KB，5页)。