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内皮素的功能及其与血管平滑肌增殖的关系
http://www.100md.com 2007年1月22日
     张俊彪,刘闺男

    摘要:冠状动脉介入治疗(Percutaneous Coronary Intervention,PCI)后再狭窄的发生机制十分复杂,目前发现涉及因素有内皮损伤、血小板激活、血管平滑肌细胞(VSMC)的迁移和增殖、细胞外基质增加、内膜增生等。

    而血管平滑肌?

    ╒SMC)的增殖和迁移在冠状动脉内支架再狭窄(In-stent Restenosis,ISR)的发生中起到了重要作用。

    近年很多研究发现:内皮素(Endothelin ,ET)可以在一定程度上促进和加速VSMC的增殖和迁移。

    因此,ET在ISR发生发展中的作用也引起了众多学者的重视。

    关键词:内皮素;支架再狭窄;血管平滑肌

    The function of ET and it’s relation of theproliferation of vascular smooth muscle cells (VSMC) ZHANG Jun-biao, LIU Gui-nan (Department of Cardiology,The First Affiliated Hospital of China Medical University, Shenyang 110001, Liaoning Province, China) Abstract: The mechanism of post Percutaneous Coronary Intervention(PCI)is very complicated,Nowadays,it is refered to many factors including endoepithelia injury 、activation of platelet 、migration and proliferation of VSMC、increasing of extracellular metrix 、proliferation of endomembrance ,and so on.Among them, the most important factors to be considered is the migration and proliferation of VSMC。

    Many researches discovered that ET could stimulate and accelerate the migration and proliferation of VSMC.So that the function of ET played in ISR has been attracted more and more savant’s attention ......

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