Researchers find no link between vaccination and type 1 diabetes
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《英国医生杂志》
A team of Danish researchers have reported finding no association between childhood vaccination and the development of type 1 diabetes (New England Journal of Medicine 2004;350:1398-404).
The research was carried out after reports linking the two were published between 1996 and 2003 in a number of medical journals, including Autoimmunity and Medical Hypotheses.
The researchers evaluated data on all children born in Denmark between the beginning of January 1990 and the end of December 2000 for whom detailed information on vaccination and type 1 diabetes was available. They used Poisson regression tools to estimate the rate ratios for type 1 diabetes according to vaccination status. They also estimated rate ratios after vaccination, given recent reports of clusters of cases of diabetes occurring two to four years after vaccination.
They found that the rate ratio for type 1 diabetes in children who received at least one dose of vaccination, compared with unvaccinated children, was 0.91 (95% confidence interval 0.74 to 1.12). They also found that the development of type 1 diabetes in children who are genetically predisposed to the disease was not significantly associated with vaccination and that there was no clustering of cases years after vaccination.
Commenting on the need for the study, Anders Hviid, leader of the research team and epidemiologist at the Statens Serum Institut, Copenhagen, said: "We believe that research into vaccine safety should be given high priority, if not for purely scientific reasons, then to reassure and to maintain public and professional confidence in vaccination.
"Unsupported hypotheses questioning vaccine safety increase antivaccination sentiment and jeopardise vaccination programmes worldwide."
He described the study as "reassuring," adding that the findings "can be communicated to parents and allay unfounded fears of vaccination."(BMJ Chibuzo Odigwe)
The research was carried out after reports linking the two were published between 1996 and 2003 in a number of medical journals, including Autoimmunity and Medical Hypotheses.
The researchers evaluated data on all children born in Denmark between the beginning of January 1990 and the end of December 2000 for whom detailed information on vaccination and type 1 diabetes was available. They used Poisson regression tools to estimate the rate ratios for type 1 diabetes according to vaccination status. They also estimated rate ratios after vaccination, given recent reports of clusters of cases of diabetes occurring two to four years after vaccination.
They found that the rate ratio for type 1 diabetes in children who received at least one dose of vaccination, compared with unvaccinated children, was 0.91 (95% confidence interval 0.74 to 1.12). They also found that the development of type 1 diabetes in children who are genetically predisposed to the disease was not significantly associated with vaccination and that there was no clustering of cases years after vaccination.
Commenting on the need for the study, Anders Hviid, leader of the research team and epidemiologist at the Statens Serum Institut, Copenhagen, said: "We believe that research into vaccine safety should be given high priority, if not for purely scientific reasons, then to reassure and to maintain public and professional confidence in vaccination.
"Unsupported hypotheses questioning vaccine safety increase antivaccination sentiment and jeopardise vaccination programmes worldwide."
He described the study as "reassuring," adding that the findings "can be communicated to parents and allay unfounded fears of vaccination."(BMJ Chibuzo Odigwe)