摘要 目的:研究手性金属配合物经Caco-2细胞单层转运吸收的手性选择性。方法:采用动力学研究方法，测定手性金属配合物跨Caco-2细胞单层的转运速率。结果:金属配合物的手性不同，导致金属配合物经Caco-2细胞单层的转运速率不同。结论:手性金属配合物经Caco-2细胞单层的转运吸收存在手性选择性的差异。

    关键词 手性;金属配合物;Caco-2细胞

    The Transport and Absorption of Chiral Metal Domplexes d，l - [Ni (phen)3]2+across the Model of Caco-2 Cell Monolayers

    MU Yongping， WU Gang， QIAO Xiuwen，ZHOU Lishe ， HE Yanling

    (Department of Biochemistry and Molecular Biology， Research Center of Biology and Medicine， Research Institute of Trace Element in Organism ， Baotou Medical College， Baotou 014010，China)

    AbstractObjective:To investigate the chiral selectivity of transport and absorption of chiral metal complexes across Caco-2 cell monolayers. Methods: To determine the transport velocity of chiral metal complexes across Caco-2 cell monolayers， using the kinetics method . Results: The difference in the chirality of metal complexes across Caco-2 cell monolayers results in the distinctness in transport velocity. Conclusions:There exists a difference in the chiral selectivity of transport and absorption of chiral metal complexes across Caco-2 cell monolayers. ......