血清P53抗体与原发性肝癌临床特征的关系
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官泳松, 刘 源, 贺 庆
血清P53抗体;原发性肝癌;临床特征;酶链免疫吸附法,官泳松,刘源,贺庆,通讯作者:,Relationshipbetweenserumanti-P53antibodyandclinicalcharacteristicsofprimaryhepaticca
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官泳松, 刘源, 贺庆, 四川大学华西医院放射科 四川省成都市 610041
通讯作者: 官泳松, 610041, 四川省成都市, 四川大学华西医院放射科. yongsongguan@yahoo.com
电话: 028-85421008 传真: 028-85538359
收稿日期: 2006-08-22 接受日期: 2006-11-02
Relationship between serum anti-P53 antibody and clinical characteristics of primary hepatic carcinoma
Yong-Song Guan, Yuan Liu, Qing He
Yong-Song Guan, Yuan Liu, Qing He,Department of Radiology, West China Hospital of Sichuan University, Chengdu 610041 Sichuan Province, China
Correspondence to: Yong-Song Guan,Department of Radiology, West China Hospital of Sichuan University, Chengdu 610041, Sichuan Province China. yongsongguan@yahoo.com
Received:2006-08-22 Accepted: 2006-11-02
Abstract
AIM: To analyze the level of serum anti-P53 antibody in primary hepatic carcinoma (PHC) as well as its correlation with clinical characteristics.
METHODS: The enzyme-linked immunosorbent assay (ELISA) was used to detect the serum level of anti-P53 antibody in 68 patients with PHC. Univariate analysis and multivariate Logistic regression analysis were performed to investigate the correlation between the serum level of P53 antibody and clinical data, including the age, sex of patients, alcohol intake, HBsAg, KPS scores, pathological findings, differentiation degree, liver cirrhosis, pattern of tumor growth, tumor stages, vascular invasion, remote metastasis, Child class, the level of serum albumin, alpha-fetoprotein (AFP) and ferritin.
RESULTS: A total of 20 patients (29.4%) were detected positive for serum anti-P53 antibody. Univariate analysis revealed that the positive status of serum P53 antibody was associated with the degree of differentiation (P = 0.020), remote metastasis (P = 0.002), tumor stages (P = 0.027) and vascular invasion (P = 0.010). Multivariate analysis showed that only remote metastasis was independently associated with the positive status of serum anti-P53 antibody (OR = 4 ......
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