消化系神经内分泌癌及文献分析209例
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蒋建霞, 施瑞华, 林 琳
消化系统;神经内分泌癌蒋建霞,施瑞华,林琳.消化系神经内分泌癌及文献分析209例. 世界华人消化杂志2007;15(4)421-426,蒋建霞,施瑞华,林琳,通讯作者:,电话:,收稿日期:,接受日期:,Neuroendocrinecarci
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蒋建霞, 施瑞华, 林琳, 南京医科大学第一附属医院消化科 江苏省南京市 210029
通讯作者: 蒋建霞, 210029, 江苏省南京市, 南京医科大学第一附属医院消化科. jjxcasey@yahoo.com.cn
电话: 025-83718836-6255
收稿日期: 2006-10-23 接受日期: 2006-11-16
Neuroendocrine carcinoma in digestive system: case analysis and literature review
Jian-Xia Jiang, Rui-Hua Shi, Lin Lin
Jian-Xia Jiang, Rui-Hua Shi, Lin Lin,Department of Gastroenterology, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, Jiangsu Province, China
Correspondence to:Jian-Xia Jiang, Department of Gastroenterology, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, Jiangsu Province,China. jjxcasey@yahoo.com.cn
Received:2006-10-23 Accepted:2006-11-16
AbstractAIM: To analyze the originating sites, clinical manifestations, endoscopic and imaging features, pathologic findings, treatments and prognosis of patients suffered from neuroendocrine carcinoma (NEC) in digestive system.
METHODS: A total of 209 cases, of which 7 cases were from our hospital and the other 202 cases were reported in literatures from 1994 to 2005, were classified as group A and B, respectively. Clinical presentation, therapy and prognosis of NEC arising from digestive system were discussed.
RESULTS: NEC mainly occurred in stomach, pancreas, rectum, esophagus, small intestine, Vater ampullae of duodenum, liver and so on, and it had a wide spectrum of clinical presentations such as abdominal pain, epigastric distention, symptoms of wasting. Periampullary NEC might cause (recurrent) acute pancreatitis, and most of them were non-functioning neoplasms. Only about 2.4% of NEC cases presented an endocrine syndrome. NEC was classified as typical carcinoid, atypical carcinoid and small cell carcinoma, and its masses varied from 0.5 to 13.0 cm in diameter, and the diagnosis of NEC depended on the features of endoscopic examination, B-ultrasound (BUS), computed tomography (CT), endoscopic retrograde cholangiopancreatography (ERCP), endoscopic ultrasonography (EUS) and pathologic findings, especially immunohistochemical markers such as synaptophysin (Syn), cytokeratin (CK), neuro-specific enolase (NSE), chromogranin A (CgA), epithelial membrane antigen (EMA) and (or) neurosecretory granules (NSG) observed through electronic microscopy ......
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