EGCG对乙酸诱导大鼠结肠炎的治疗作用及抗氧化机制
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冉志华, 陈 迟, 萧树东
表没食子儿茶素没食子酸酯;结肠炎;抗氧化;机制冉志华,陈迟,萧树东.EGCG对乙酸诱导大鼠结肠炎的治疗作用及抗氧化机制. 世界华人消化杂志2007;15(4)359-364 结肠炎大鼠光镜下组织学观察(HE×200).A正常组;B模型安慰剂组;CEGCG组;DSASP组.,E
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冉志华, 陈迟, 萧树东, 上海交通大学医学院附属仁济医院消化内科 上海市消化疾病研究所 上海市 200001
冉志华, 1999年德国海德堡大学医学系博士毕业, 教授, 博士生导师, 主要从事炎症性肠病和消化道肿瘤研究.上海市重点学科建设资助项目, No. Y0205
通讯作者: 冉志华, 200001, 上海市山东中路145号, 上海市消化疾病研究所. z-ran@online.sh.cn
电话: 021-63200874 传真: 021-63266027
收稿日期: 2006-10-18 接受日期: 2006-11-16
Therapeutic effect and antioxidation mechanism of epigallocatechin-3-gallate in rats with colitis induced by acetic acid
Zhi-Hua Ran, Chi Chen, Shu-Dong Xiao
Zhi-Hua Ran, Chi Chen, Shu-Dong Xiao, Department of Gastroenterology, Renji Hospital Affiliated to Medical College of Shanghai Jiao Tong University; Shanghai Institute of Digestive Diseases, Shanghai 200001, China
Supported by the Leading Academic Discipline Project of Shanghai Municipality, No. Y0205
Correspondence to: Dr. Zhi-Hua Ran, Department of Gastroenterology, Renji Hospital Affiliated to Medical College of Shanghai Jiao Tong University; Shanghai Institute of Digestive Diseases, Shanghai 200001, China. z-ran@online.sh.cn
Received: 2006-10-18 Accepted: 2006-11-16
AbstractAIM: To investigate the therapeutic effect and antioxidation mechanism of epigallocatechin-3-gallate (EGCG) in rats with acetic acid-induced colitis.
METHODS: Sixty male rats were randomly assigned into 4 groups: normal control (n = 10), model placebo (n = 20), EGCG (n = 15), sulfasalazine (SASP, n = 15). The rats in normal group were treated with regular feeding, while those in the other three groups were treated orally with normal saline (2 mL/d), EGCG [50 mg/(kg·d)], and SASP [0.25 g(kg·d)] respectively for 7 days after the colitis model was induced by 80 g/L acetic acid. The general condition, food intake, weight, stool consistency, and bloody stool were observed, and then the disease activity index (DAI) and the therapeutic effects were evaluated. All the rats were sacrificed on day 8 ......
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